Neoadjuvantní chemoradioterapie karcinomu rekta v kombinaci s inhibitory receptoru pro růstový epidermální faktor
[The combination of neoadjuvant chemoradiotherapy and epidermal growth factor receptor inhibitors in the treatment of rectal adenocarcinoma]
Jazyk čeština Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24918274
DOI
10.14735/amko2014166
PII: 48816
- MeSH
- adenokarcinom terapie MeSH
- adjuvantní chemoradioterapie metody MeSH
- capecitabinum MeSH
- deoxycytidin aplikace a dávkování analogy a deriváty MeSH
- erbB receptory antagonisté a inhibitory metabolismus MeSH
- fluoruracil aplikace a dávkování analogy a deriváty MeSH
- lidé MeSH
- nádory rekta metabolismus terapie MeSH
- neoadjuvantní terapie metody MeSH
- protokoly protinádorové kombinované chemoterapie terapeutické užití MeSH
- tolerance záření MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- capecitabinum MeSH
- deoxycytidin MeSH
- erbB receptory MeSH
- fluoruracil MeSH
Rectal adenocarcinoma, in contrast to colorectal carcinoma, is typical of its high local reccurence rate. Radiotherapy is proved to reduce the incidence of recurrences. Neoadjuvant chemoradiotherapy demonstrated better treatment results than adjuvant chemoradiotherapy. Standard cytotoxic agents involved in combination therapy are 5- flurouracil or capecitabin. Epidermal growth factor receptor (EGFR) is supposed to play an important role in cell- cycle regulation, proliferation, differentiation, and surviving of normal epithelial tissues. EGFR overexpression in patients with rectal adenocarcinoma is associated with radioresistance of malignant tissues, lower rates of patological complete response after neoadjuvant chemoradiation and generally poor survival. There are many clinical studies describing combination of neoadjuvant chemoradiotherapy with EGFR inhibitors, however, this regimen has not gained an acceptance as a standard of treatmentment.
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