Functionalized nanofibers as drug-delivery systems for osteochondral regeneration
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24978465
DOI
10.2217/nnm.14.57
Knihovny.cz E-resources
- Keywords
- bone, cartilage, drug delivery, electrospinning, liposome, nanofiber,
- MeSH
- Cartilage cytology MeSH
- Drug Delivery Systems methods MeSH
- Humans MeSH
- Nanofibers chemistry MeSH
- Bone Regeneration physiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
A wide range of drug-delivery systems are currently attracting the attention of researchers. Nanofibers are very interesting carriers for drug delivery. This is because nanofibers are versatile, flexible, nanobiomimetic and similar to extracellular matrix components, possible to be functionalized both on their surface as well as in their core, and also because they can be produced easily and cost effectively. There have been increasing attempts to use nanofibers in the construction of a range of tissues, including cartilage and bone. Nanofibers have also been favorably engaged as a drug-delivery system in cell-free scaffolds. This short overview is devoted to current applications and to further perspectives of nanofibers as drug-delivery devices in the field of cartilage and bone regeneration, and also in osteochondral reconstruction.
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