The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24995701
DOI
10.1016/j.ejps.2014.06.017
PII: S0928-0987(14)00277-2
Knihovny.cz E-zdroje
- Klíčová slova
- Agomelatine, Co-crystal, DITA, Solubility, Ternary phase diagram,
- MeSH
- kalorimetrie MeSH
- krystalizace MeSH
- kyselina citronová chemie MeSH
- léčivé přípravky chemie MeSH
- rozpouštědla chemie MeSH
- rozpustnost MeSH
- teplota MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kyselina citronová MeSH
- léčivé přípravky MeSH
- rozpouštědla MeSH
Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. In recent years, the advances in crystal engineering have motivated the research in the design of pharmaceutical co-crystals. This study examines the combination of solvent selection and co-crystal ternary phase diagram prediction on the basis of solubility measurements into a single methodology that can be integrated into the pharmaceutical process development workflow. Ternary diagrams constructed from agomelatine citric acid co-crystal solubility data were compared with those obtained by modern calorimetric method called discontinuous isoperibolic thermal analysis (DITA). A suitable solvent for the co-crystallization process has been chosen on the basis of agomelatine citric acid co-crystal solubility, which is connected to the yield of the crystallization process. Furthermore, the quality of final crystals from crystallization experiments was evaluated.
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Citace poskytuje Crossref.org
Surface Defects and Crystal Growth of Apremilast Benzoic Acid Cocrystals
