The role of adipose tissue immune cells in obesity and low-grade inflammation
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
25006217
DOI
10.1530/joe-14-0283
PII: JOE-14-0283
Knihovny.cz E-zdroje
- Klíčová slova
- adaptive immunity, adipose tissue, immune cells, innate immunity, insulin resistance, low-grade inflammation,
- MeSH
- inzulinová rezistence imunologie MeSH
- lidé MeSH
- lymfocyty imunologie patologie MeSH
- myeloidní buňky imunologie patologie MeSH
- obezita etiologie imunologie patologie MeSH
- tuková tkáň imunologie metabolismus patologie MeSH
- zánět etiologie imunologie patologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis. Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. This review has focused on the various subsets of immune cells in AT and their role in the development of AT inflammation and obesity-induced insulin resistance.
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