JavaScript is NOT enabled !

Please enable JavaScript.

Article

PubMed

This record comes from PubMed

Fibrinolysis for intraventricular hemorrhage: an updated meta-analysis and systematic review of the literature

Khan, Nickalus R
Author Khan, Nickalus R From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.). nkhan4@uthsc.edu
Tsivgoulis, Georgios
Author Tsivgoulis, Georgios From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Lee, Siang Liao
Author Lee, Siang Liao From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Jones, G Morgan
Author Jones, G Morgan From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Green, Cain S
Author Green, Cain S From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Katsanos, Aristeidis H
Author Katsanos, Aristeidis H From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Klimo, Paul Jr
Author Klimo, Paul From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Arthur, Adam S
Author Arthur, Adam S From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Elijovich, Lucas
Author Elijovich, Lucas From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)
Alexandrov, Andrei V
Author Alexandrov, Andrei V From the Department of Neurosurgery (N.R.K., G.M.J., P.K., A.S.A., L.E.), Department of Neurology (G.T., G.M.J., L.E., A.V.A.), Department of Clinical Pharmacy (G.M.J.), and College of Medicine (C.S.G.), University of Tennessee Health Sciences Center, Memphis; Second Department of Neurology, Attikon University Hospital, School of Medicine, University of Athens, Athens, Greece (G.T.); International Clinical Research Center, Department of Neurology, St. Anne's University Hospital, Brno, Czech Republic (G.T.); Feinberg School of Medicine, Northwestern University, Chicago, IL (S.L.L.); Department of Neurology, University of Ioannina, School of Medicine, Ipiros, Greece (A.H.K.); and Semmes-Murphey Neurologic & Spine Institute, Memphis, TN (P.K., A.S.A., L.E.)

Stroke. 2014 Sep ; 45 (9) : 2662-9. [epub] 20140722

ISSN 1524-4628 | 0039-2499
Source

Language English Country United States Media print-electronic

Document type Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review

Persistent link https://www.medvik.cz/link/pmid25052321

PubMed 25052321
DOI 10.1161/strokeaha.114.005990
PII: STROKEAHA.114.005990
Knihovny.cz E-resources

Keywords
fibrinolysis, meta-analysis,
MeSH
Cerebral Hemorrhage mortality therapy MeSH
Clinical Trials as Topic MeSH
Humans MeSH
Recurrence MeSH
Risk MeSH
Thrombolytic Therapy methods MeSH
Treatment Outcome MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH
Meta-Analysis MeSH
Research Support, Non-U.S. Gov't MeSH
Review MeSH
Systematic Review MeSH

BACKGROUND AND PURPOSE: Intraventricular hemorrhage is associated with high mortality and poor functional outcome. The use of intraventricular fibrinolytic (IVF) therapy as an intervention in intraventricular hemorrhage is an evolving therapy with conflicting reports in the literature. The goal of this study is to investigate the impact of IVF on mortality, functional outcome, ventriculitis, shunt dependence, and rehemorrhage. METHODS: During March and April 2014, a systematic literature search was performed identifying 1359 articles. Of these, 24 met inclusion criteria. A random effects meta-analysis was performed using both pooled and subset analysis based on study type. RESULTS: Our meta-analysis demonstrated that IVF reduced mortality in intraventricular hemorrhage by nearly half (relative risk [RR], 0.55; 95% confidence interval [CI], 0.42-0.71; P<0.00001), increased the likelihood of good functional outcome by 66% (RR, 1.66; 95% CI, 1.27-2.19; P=0.0003), and also decreased the rate of shunt dependence (RR, 0.62; 95% CI, 0.42-0.93; P=0.02). IVF was not found to be associated with increased rates of ventriculitis (RR=1.46; 95% CI, 0.77-2.76; P=0.25) or rehemorrhage (RR=1.06; 95% CI, 0.66-1.70; P=0.80). We detected no evidence of publication bias. CONCLUSIONS: Our meta-analysis showed that IVF is safe and could be an effective strategy for the treatment of intraventricular hemorrhage. It may reduce mortality, improve functional outcome, and diminish the need for permanent ventricular shunting, while not increasing the risk of ventriculitis or rehemorrhage.

From the Department of Neurosurgery

Comment In

Stroke. 2014 Nov;45(11):e236. doi: 10.1161/STROKEAHA.114.007164. PubMed

Comment In

Stroke. 2014 Nov;45(11):e235. doi: 10.1161/STROKEAHA.114.007150. PubMed

References provided by Crossref.org

Newest 20 citations...

See more in
Medvik | PubMed

Mechanical thrombectomy for emergent large vessel occlusion: a critical appraisal of recent randomized controlled clinical trials

Brain and behavior. 2016 Feb ; 6 (2) : e00418. [epub] 20160107

Brain Behav
ISSN 2162-3279
Source

Systemic thrombolysis in acute ischemic stroke patients with unruptured intracranial aneurysms