Narrow band imaging is considered a significant improvement in the possibility of detecting early mucosal lesion of the upper aerodigestive tract. Early detection of mucosal neoplastic lesions is of utmost importance for patients survival. There is evidence that, especially in patients previously treated by means of curative radiotherapy or chemoradiotherapy, the early detection rate of recurrent disease is quite low. The aim of this study was to prove whether the videoendoscopy coupled with NBI might help detect recurrent or secondary tumors of the upper aerodigestive tract. 66 patients previously treated by means of RT or CRT with curative intent were enrolled in the study. All patients underwent transnasal flexible videoendoscopy with NBI mode under local anesthesia. When a suspicious lesion was identified in an ambulatory setting, its nature was proved histologically. Many of these changes were not identifiable by means of conventional white light (WL) endoscopy. The accuracy, sensitivity, specificity, and positive and negative predictive value of the method are very high (88%, 92%, 76%, 96%, and 91%, resp.). Results demonstrate that outpatient transnasal endoscopy with NBI is an excellent method for the follow-up of patients with carcinomas of the larynx and the hypopharynx primarily treated with radiotherapy.

Department of Otorhinolaryngology and Head and Neck Surgery 1st Faculty of Medicine Charles University University Hospital Motol 5 Úvalu 84 150 06 Prague 5 Czech Republic

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Rennemo E, Zätterström U, Boysen M. Impact of second primary tumors on survival in head and neck cancer: an analysis of 2,063 cases. Laryngoscope. 2008;118(8):1350–1356. PubMed

Cooper JS. Late effects of radiation therapy in the head and neck region. International Journal of Radiation Oncology Biology Physics. 1995;31(5):1141–1164. PubMed

Sharma S, Sharma MC, Sarkar C. Morphology of angiogenesis in human cancer: a conceptual overview, histoprognostic perspective and significance of neoangiogenesis. Histopathology. 2005;46(5):481–489. PubMed

Ni X-G, He S, Xu Z-G, et al. Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. The Journal of Laryngology and Otology. 2011;125(3):288–296. PubMed

O'Brien PC. Tumour recurrence or treatment sequelae following radiotherapy for larynx cancer. Journal of Surgical Oncology. 1996;63(2):130–135. PubMed

Lowe VJ, Boyd JH, Dunphy FR, et al. Surveillance for recurrent head and neck cancer using positron emission tomography. Journal of Clinical Oncology. 2000;18(3):651–658. PubMed

Zbären P, Caversaccio M, Thoeny HC, Nuyens M, Curschmann J, Stauffer E. Radionecrosis or tumor recurrence after radiation of laryngeal and hypopharyngeal carcinomas. Otolaryngology—Head and Neck Surgery. 2006;135(6):838–843. PubMed

Ganly I, Patel SG, Matsuo J, et al. Results of surgical salvage after failure of definitive radiation therapy for early-stage squamous cell carcinoma of the glottic larynx. Archives of Otolaryngology— Head and Neck Surgery. 2006;132(1):59–66. PubMed

Fu KK. The endolarynx and hypopharynx. In: Cox JD, editor. Moss Radiation Oncology: Rationale, Technique, Results. St. Louis, Mo, USA: Mosby; 1994. p. p. 214.

Filntisis GA, Farmer JC, Moon RE, Scher RL, Kraft KL, Piantadosi CA. Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature. Annals of Otology, Rhinology and Laryngology. 2000;109(6):554–562. PubMed

Kim JW, Roh JL, Kim JS, et al. PET/CT surveillance at 3–6 and 12 months for detection of recurrence and second primary cancer in patients with head and neck squamous cell carcinoma. British Journal of Cancer. 2013;109(12):2973–2979. PubMed PMC

Kostakoglu L, Fardanesh R, Posner M. Early detection of recurrent disease by FDG-PET/CT leads to management changes in patients with squamous cell cancer of the head and neck. Oncologist. 2013;18(10):1108–1117. PubMed PMC

Zbären P, Christe A, Caversaccio MD, Stauffer E, Thoeny HC. Pretherapeutic staging of recurrent laryngeal carcinoma: clinical findings and imaging studies compared with histopathology. Otolaryngology-Head and Neck Surgery. 2007;137(3):487–491. PubMed

Lukes P, Zabrodsky M, Plzak J, et al. Narrow band imaging (NBI)—endoscopic method for detection of head and neck cancer. In: Amornyotin S, editor. Endoscopy. Rijeka, Croatia: InTech; 2013. pp. 75–87.

Watanabe A, Tsujie H, Taniguchi M, Hosokawa M, Fujita M, Sasaki S. Laryngoscopic detection of pharyngeal carcinoma in situ with narrowband imaging. Laryngoscope. 2006;116(4):650–654. PubMed

Kato M, Kaise M, Yonezawa J, et al. Magnifying endoscopy with narrow-band imaging achieves superior accuracy in the differential diagnosis of superficial gastric lesions identified with white-light endoscopy: a prospective study. Gastrointestinal Endoscopy. 2010;72(3):523–529. PubMed

Matsuba H, Katada C, Masaki T, et al. Diagnosis of the extent of advanced oropharyngeal and hypopharyngeal cancers by narrow band imaging with magnifying endoscopy. Laryngoscope. 2011;121(4):753–759. PubMed

Piazza C, del Bon F, Peretti G, Nicolai P. Narrow band imaging in endoscopic evaluation of the larynx. Current Opinion in Otolaryngology and Head and Neck Surgery. 2012;20(6):472–476. PubMed

Wu L, Li Y, Li Z, Cao Y, Gao F. Diagnostic accuracy of narrow-band imaging for the differentiation of neoplastic from non-neoplastic colorectal polyps: a meta-analysis. Colorectal Disease. 2013;15(1):3–11. PubMed

Piazza C, Cocco D, De Benedetto L, Bon FD, Nicolai P, Peretti G. Role of narrow-band imaging and high-definition television in the surveillance of head and neck squamous cell cancer after chemo- and/or radiotherapy. European Archives of Oto-Rhino-Laryngology. 2010;267(9):1423–1428. PubMed

Lin Y, Watanabe A, Chen W, Lee K, Lee I, Wang W. Narrowband imaging for early detection of malignant tumors and radiation effect after treatment of head and neck cancer. Archives of Otolaryngology—Head and Neck Surgery. 2010;136(3):234–239. PubMed

Piazza C, Cocco D, del Bon F, Mangili S, Nicolai P, Peretti G. Narrow band imaging and high definition television in the endoscopic evaluation of upper aero-digestive tract cancer. Acta Otorhinolaryngologica Italica. 2011;31(2):70–75. PubMed PMC

Nonaka S, Saito Y. Endoscopic diagnosis of pharyngeal carcinoma by NBI. Endoscopy. 2008;40(4):347–351. PubMed

Evolution of mucosal vasculature after radiotherapy of T1 vocal cord cancer: a pilot study

Narrative Review of Classification Systems Describing Laryngeal Vascularity Using Advanced Endoscopic Imaging

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors

Comparison of narrow band imaging and the Storz Professional Image Enhancement System for detection of laryngeal and hypopharyngeal pathologies