Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25132312
DOI
10.1039/c4nr02776k
Knihovny.cz E-resources
- MeSH
- Acrylamides chemistry MeSH
- Biocompatible Materials chemistry MeSH
- Click Chemistry MeSH
- Peptides, Cyclic chemistry metabolism MeSH
- Endocytosis MeSH
- Fluorescent Dyes chemistry MeSH
- Glioma metabolism pathology MeSH
- Integrin alphaVbeta3 chemistry metabolism MeSH
- Microscopy, Confocal MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Nanodiamonds chemistry toxicity MeSH
- Silicon Dioxide chemistry MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acrylamides MeSH
- Biocompatible Materials MeSH
- cyclic arginine-glycine-aspartic acid peptide MeSH Browser
- Peptides, Cyclic MeSH
- Fluorescent Dyes MeSH
- Integrin alphaVbeta3 MeSH
- N-(2-hydroxypropyl)methacrylamide MeSH Browser
- Nanodiamonds MeSH
- Silicon Dioxide MeSH
Core-shell nanoparticles based on fluorescent nanodiamonds coated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer shell were developed for background-free near-infrared imaging of cancer cells. The particles showed excellent colloidal stability in buffers and culture media. After conjugation with a cyclic RGD peptide they selectively targeted integrin αvβ3 receptors on glioblastoma cells with high internalization efficacy.
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