Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
P30 CA008748
NCI NIH HHS - United States
PubMed
25240283
PubMed Central
PMC10208689
DOI
10.1038/ng.3096
PII: ng.3096
Knihovny.cz E-zdroje
- MeSH
- adenokarcinom genetika patologie MeSH
- buňky NIH 3T3 MeSH
- imunohistochemie MeSH
- imunoprecipitace MeSH
- konfokální mikroskopie MeSH
- lidé MeSH
- missense mutace genetika MeSH
- molekulární modely * MeSH
- molekulární sekvence - údaje MeSH
- mutageneze MeSH
- myši MeSH
- nádory slinných žláz genetika patologie MeSH
- proteinkinasa C chemie genetika MeSH
- sekvence aminokyselin MeSH
- sekvenční analýza DNA MeSH
- sekvenční seřazení MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- protein kinase D MeSH Prohlížeč
- proteinkinasa C MeSH
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
] Department of Pathology Memorial Sloan Kettering Cancer Center New York New York USA [2]
Cancer Genomics Platform Ontario Institute for Cancer Research Toronto Ontario Canada
Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA
Department of Pathology and Laboratory Medicine Charles University Prague Plzen Czech Republic
Department of Pathology Memorial Sloan Kettering Cancer Center New York New York USA
Department of Pathology University Health Network Toronto Ontario Canada
Department of Pathology University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA
Department of Pathology University of Virginia Medical Center Charlottesville Virginia USA
Department of Pathology Virginia Mason Hospital and Seattle Medical Center Seattle Washington USA
Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA
Informatics and Bio Computing Program Ontario Institute for Cancer Research Toronto Ontario Canada
Zobrazit více v PubMed
Barnes L, Eveson J, Reichart P & Sidransky D Pathology And Genetics of Head and Neck Tumours, (IARC Press, 2005).
Foschini MP & Eusebi V Pathology 41,48–56(2009). PubMed
Evans HL & Luna MA Am J Surg Pathol 24,1319–1328(2000). PubMed
Perez-Ordonez B, Linkov I & Huvos AG Histopathology 32,521–529(1998). PubMed
Weinreb I Adv Anat Pathol 20,367–377(2013). PubMed
Cappuzzo F et al. J Natl Cancer Inst 97,643–655(2005). PubMed
Rozengurt E Physiology (Bethesda) 26,23–33(2011). PubMed PMC
Gao J et al. Sci Signal 6,pl1(2013). PubMed PMC
Forbes SA et al. Nucleic Acids Res 39,D945–950(2011). PubMed PMC
Debnath J, Muthuswamy SK & Brugge JS Methods 30,256–268(2003). PubMed
Debnath J & Brugge JS Nat Rev Cancer 5,675–688(2005). PubMed
Weigelt B, Geyer FC & Reis-Filho JS Mol Oncol 4,192–208(2010). PubMed PMC
Polymorphous adenocarcinoma of the salivary glands: reappraisal and update
Newly described salivary gland tumors
SRA
SRP045782, SRP045785