Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adult MeSH
- Stress, Physiological genetics MeSH
- Pregnancy Complications diagnosis genetics metabolism physiopathology MeSH
- Blood Pressure MeSH
- Humans MeSH
- RNA, Messenger * MeSH
- Placenta metabolism MeSH
- Pre-Eclampsia diagnosis genetics metabolism physiopathology MeSH
- Heat-Shock Proteins genetics MeSH
- Gene Expression Regulation MeSH
- Retrospective Studies MeSH
- Fetal Growth Retardation diagnosis genetics metabolism MeSH
- Severity of Illness Index MeSH
- Pregnancy MeSH
- Ultrasonography, Doppler, Color MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- RNA, Messenger * MeSH
- Heat-Shock Proteins MeSH
The study describes the stress response in the central cotyledon zone of placental tissue and in maternal whole peripheral blood to pregnancy related complications including gestational hypertension (n = 31), preeclampsia w or w/o fetal growth restriction (n = 95), and fetal growth restriction (n = 39) using real-time RT-PCR and genes encoding Hsp27, Hsp60, Hsp70, Hsp90 and HspBP1 proteins. The placental tissue does not respond to pregnancy induced hypertension, fetal growth restriction and short-term severe preeclampsia that requires immediate termination of gestation. Upregulation of Hsp27, Hsp90 and HspBP1 appears just in case of long-term deteriorated conditions (usually in mild preeclampsia, that enable further continuation of gestation, when properly treated). On the other hand, maternal circulation is able to reflect both maternal and fetal pathologic conditions. While pregnancy related complications always induce upregulation of Hsp70 and downregulation of Hsp90 in maternal whole peripheral blood, the increase of Hsp60 mRNA levels occurs entirely in patients with preeclampsia and/or fetal growth restriction. Hsp60, Hsp70 and Hsp90 are dysregulated in maternal circulation irrespective of the severity of the disease (in both mild and severe preeclampsia) and the requirements for the delivery (before and after 34th week of gestation). Nevertheless, the highest Hsp60 mRNA levels may be observed in pregnancies with signs of the centralization of the fetal circulation associated with fetal hypoxia.
See more in PubMed
J Reprod Immunol. 2014 Mar;101-102:89-95 PubMed
Pathol Res Pract. 2010 Sep 15;206(9):651-6 PubMed
J Biol Chem. 1998 Dec 4;273(49):32883-8 PubMed
Cell Stress Chaperones. 2010 May;15(3):237-47 PubMed
J Hum Hypertens. 2006 Oct;20(10):780-6 PubMed
Am J Obstet Gynecol. 1979 Sep 1;135(1):48-52 PubMed
J Obstet Gynaecol Res. 2005 Feb;31(1):72-7 PubMed
BMB Rep. 2009 Oct 31;42(10):623-30 PubMed
Expert Rev Mol Med. 2000 Sep 15;2(8):1-17 PubMed
Mol Immunol. 2010 Apr;47(7-8):1500-6 PubMed
Gynecol Obstet Invest. 1995;40(4):236-43 PubMed
Clin Exp Immunol. 2006 Jul;145(1):183-9 PubMed
PLoS One. 2013;8(1):e54540 PubMed
Eur J Obstet Gynecol Reprod Biol. 2008 Aug;139(2):133-8 PubMed
J Reprod Immunol. 2013 Dec;100(2):129-34 PubMed
Br J Obstet Gynaecol. 1990 Sep;97(9):797-803 PubMed
Am J Obstet Gynecol. 1974 Nov 15;120(6):817-24 PubMed
Am J Physiol. 1999 Nov;277(5):L1026-33 PubMed
Clin Exp Obstet Gynecol. 2004;31(1):12-4 PubMed
Am J Obstet Gynecol. 1988 Jan;158(1):80-3 PubMed
BMC Immunol. 2010 Dec 02;11:59 PubMed
Mol Med. 2008 Sep-Oct;14(9-10):561-6 PubMed
Gynecol Obstet Invest. 2011;71(3):151-7 PubMed
Cell Stress Chaperones. 2009 Mar;14(2):151-9 PubMed
J Reprod Immunol. 2007 Apr;73(2):172-179 PubMed
Nature. 1994 Jul 14;370(6485):111-7 PubMed
Cell Biochem Biophys. 2012 Dec;64(3):187-95 PubMed
Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):499-506 PubMed
Br J Obstet Gynaecol. 1986 Oct;93(10):1049-59 PubMed
Wien Klin Wochenschr. 2002 Aug 30;114(15-16):730-2 PubMed
Cancer Res. 1996 Jan 15;56(2):273-9 PubMed
Biochem Cell Biol. 2010 Apr;88(2):291-300 PubMed
EMBO J. 1994 Dec 15;13(24):6099-106 PubMed
Clin Chim Acta. 2011 Oct 9;412(21-22):1957-62 PubMed
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):836-40 PubMed
Cell Stress Chaperones. 2003 Winter;8(4):303-8 PubMed
Autoimmun Rev. 2007 Aug;6(7):438-43 PubMed
Early Hum Dev. 1992 Jun-Jul;29(1-3):259-67 PubMed
Biochem Biophys Res Commun. 1997 Dec 8;241(1):187-92 PubMed
Infect Dis Obstet Gynecol. 1999;7(4):180-5 PubMed
Med Electron Microsc. 2004 Sep;37(3):170-6 PubMed
Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications
