Development and characterization of metal oxide nanoparticles for the delivery of anticancer drug
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
- Keywords
- Zinc oxide, anticancer, doxorubicin, drug delivery, nanoparticles,
- MeSH
- Doxorubicin chemistry pharmacology MeSH
- Humans MeSH
- MCF-7 Cells MeSH
- Nanoparticles * MeSH
- Drug Carriers chemistry toxicity MeSH
- Zinc Oxide chemistry toxicity MeSH
- Antineoplastic Agents chemistry pharmacology MeSH
- Drug Liberation MeSH
- Particle Size MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Doxorubicin MeSH
- Drug Carriers MeSH
- Zinc Oxide MeSH
- Antineoplastic Agents MeSH
The aim of the study was to prepare chemotherapeutic agent-loaded zinc oxide nanoparticles for the intracellular delivery of drug, for better therapeutic activity. Zinc oxide nanoparticles have inherent anticancer properties, hence it was envisaged that by loading the anticancer drug into zinc oxide nanoparticles, enhanced anticancer activity might be observed. Zinc oxide nanoparticles were prepared using zinc nitrate and sodium hydroxide. Starch was used as the stabilizing agent. The nanoparticles prepared were characterized for size, shape, entrapment efficiency, and drug release. Further, cell line studies were performed to evaluate cellular uptake and cytotoxicity profile using MCF-7 cells. A hemolysis study was performed to check the acute toxicity of the nanoparticles. The nanoparticles were found to be 476.4 ± 2.51 nm in size, with low PDI (0.312 ± 0.02) and high entrapment efficiency (> 85%). The nanoparticles were stable, and did not form aggregates on storage in the dispersed form. A cytotoxicity study demonstrated that drug-loaded zinc oxide nanoparticles exhibited higher anticancer activity as compared to either blank zinc oxide nanoparticles and doxorubicin (DOX) alone, or their mixture. A hemolytic test revealed that the prepared zinc oxide nanoparticles caused negligible hemolysis. Thus, it can be concluded that zinc oxide nanoparticles loaded with DOX resulted in better uptake of the chemotherapeutic agent, and at the same time, showed low toxicity towards normal cells.
b Department of Wood Science Mendel University in Brno Brno Czech Republic
c School of Pharmacy Keck Graduate Institute Claremont CA USA
Department of Pharmaceutics ISF College of Pharmacy Punjab India
References provided by Crossref.org
Metal Oxide Nanoparticles: Review of Synthesis, Characterization and Biological Effects
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