A highly diverse spectrum of naphthoquinone derivatives produced by the endophytic fungus Biatriospora sp. CCF 4378
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- Ascomycota klasifikace genetika izolace a purifikace metabolismus MeSH
- buněčné linie MeSH
- endofyty klasifikace genetika izolace a purifikace metabolismus MeSH
- lidé MeSH
- molekulární struktura MeSH
- naftochinony chemie metabolismus farmakologie MeSH
- Ulmus mikrobiologie MeSH
- viabilita buněk účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- naftochinony MeSH
A strain of Biatriospora sp. CCF 4378 was tested for the production of secondary metabolites under submerged fermentation conditions. Eleven compounds were isolated from the culture broth, and the structures of these compounds were determined using HRMS, NMR and X-ray analysis. In addition to six known naphthoquinone derivatives, i.e. ascomycone A, ascomycone B, 6-deoxyfusarubine, 6-deoxyanhydrofusarubine, herbarine and balticol A, one derivative of 2-azaanthraquinone, 6-deoxybostrycoidine, was also identified. Four new natural pyranonaphthoquinones were found, and these natural products were pleorubrin A, pleorubrin B, pleorubrin C and pleorubrin D. The toxicity on human cell lines of the crude naphthoquinone fraction and pure 6-deoxybostrycoidin, ascomycone B, pleorubrin B and 6-deoxyfusarubin was tested. Ascomycone B and 6-deoxyfusarubin elicited rapid cytotoxicity at micromolar concentrations.
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Phytochemistry. 2002 Aug;60(7):741-5 PubMed
Nat Prod Rep. 1999 Jun;16(3):267-81 PubMed
J Agric Food Chem. 2004 Jun 30;52(13):4109-12 PubMed
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1079-82 PubMed
Mycopathologia. 1990 Jul;111(1):9-15 PubMed
J Nat Prod. 2002 May;65(5):730-3 PubMed
J Nat Prod. 2007 Nov;70(11):1700-5 PubMed
J Antibiot (Tokyo). 1974 Apr;27(4):283-7 PubMed
Z Naturforsch C. 2009 Jan-Feb;64(1-2):25-31 PubMed
Chem Biodivers. 2009 Feb;6(2):127-37 PubMed
J Nat Prod. 2008 Mar;71(3):426-30 PubMed
Nat Prod Commun. 2013 Sep;8(9):1223-6 PubMed
Mycologia. 2012 Jan-Feb;104(1):198-210 PubMed
Microb Ecol. 2013 Oct;66(3):682-700 PubMed
N Biotechnol. 2013 Sep 25;30(6):685-94 PubMed
J Nat Prod. 2008 Nov;71(11):1973-6 PubMed
Cancer Biol Ther. 2006 Nov;5(11):1523-9 PubMed
Mar Drugs. 2011;9(5):844-51 PubMed
Stud Mycol. 2009;64:155-173S6 PubMed
Nat Prod Rep. 2008 Apr;25(2):376-400 PubMed
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22 PubMed
Pest Manag Sci. 2003 Jun-Jul;59(6-7):736-47 PubMed
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 PubMed
