Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25545116
DOI
10.1111/pim.12168
Knihovny.cz E-resources
- Keywords
- Ixodes ricinus, MCP-1, Th2 response, chemokine, histamine, tick saliva,
- MeSH
- Chemokine CCL1 immunology MeSH
- Chemokine CCL2 immunology MeSH
- Chemokine CXCL2 immunology MeSH
- Ixodes immunology MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Specific Pathogen-Free Organisms MeSH
- Saliva immunology MeSH
- Th2 Cells immunology MeSH
- Histamine Release MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chemokine CCL1 MeSH
- Chemokine CCL2 MeSH
- Chemokine CXCL2 MeSH
The effect of Ixodes ricinus tick saliva on the production of various cytokines and chemokines by mouse splenocytes was tested by a cytokine array. We demonstrated a strong upregulation of three chemokines, monocyte chemoattractant protein-1 (MCP-1), thymus-derived chemotactic agent 3 (TCA-3) and macrophage inflammatory protein 2 (MIP-2). MCP-1 could be induced by tick saliva itself. While TCA-3 and MIP-2 are engaged in Th2 polarization of the host immune response associated with tick feeding, MCP-1 may act as a histamine release factor, increasing blood flow into the feeding lesion thus facilitating tick engorgement in the late, rapid feeding phase.
References provided by Crossref.org
Modulation of host immunity by tick saliva
