Tick saliva increases production of three chemokines including monocyte chemoattractant protein-1, a histamine-releasing cytokine
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25545116
DOI
10.1111/pim.12168
Knihovny.cz E-zdroje
- Klíčová slova
- Ixodes ricinus, MCP-1, Th2 response, chemokine, histamine, tick saliva,
- MeSH
- chemokin CCL1 imunologie MeSH
- chemokin CCL2 imunologie MeSH
- chemokin CXCL2 imunologie MeSH
- klíště imunologie MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- organismy bez specifických patogenů MeSH
- sliny imunologie MeSH
- Th2 buňky imunologie MeSH
- uvolňování histaminu MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- chemokin CCL1 MeSH
- chemokin CCL2 MeSH
- chemokin CXCL2 MeSH
The effect of Ixodes ricinus tick saliva on the production of various cytokines and chemokines by mouse splenocytes was tested by a cytokine array. We demonstrated a strong upregulation of three chemokines, monocyte chemoattractant protein-1 (MCP-1), thymus-derived chemotactic agent 3 (TCA-3) and macrophage inflammatory protein 2 (MIP-2). MCP-1 could be induced by tick saliva itself. While TCA-3 and MIP-2 are engaged in Th2 polarization of the host immune response associated with tick feeding, MCP-1 may act as a histamine release factor, increasing blood flow into the feeding lesion thus facilitating tick engorgement in the late, rapid feeding phase.
Citace poskytuje Crossref.org
Modulation of host immunity by tick saliva
