Maghemite based silicone composite for arterial embolization hyperthermia
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25579966
DOI
10.1016/j.msec.2014.12.046
PII: S0928-4931(14)00844-3
Knihovny.cz E-resources
- Keywords
- Arterial embolization hyperthermia, Embolic material, Maghemite nanoparticles, Radiopacity, Rheological properties, Specific loss power,
- MeSH
- Hyperthermia, Induced * MeSH
- Potassium Iodide chemistry MeSH
- Humans MeSH
- Magnetic Fields * MeSH
- Nanocomposites chemistry MeSH
- Elasticity MeSH
- Silicones chemistry MeSH
- Embolization, Therapeutic * MeSH
- Ferric Compounds chemistry MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- ferric oxide MeSH Browser
- Potassium Iodide MeSH
- Silicones MeSH
- Ferric Compounds MeSH
Maghemite nanoparticle based silicone composite for application in arterial embolization hyperthermia is developed. It possesses embolization ability, high heating efficiency in alternating magnetic fields and radiopaque property. The initial components of the composite are selected so that the material stays liquid for 20min, providing the opportunity for transcatheter transportation and filling of the tumour vascular system. After this induction period the viscosity increases rapidly and soft embolus is formed which is able to occlude the tumour blood vessels. The composite is thermally stable up to 225°C, displays rubber-elastic properties and has a thermal expansion coefficient higher than that of blood. Maghemite nanoparticles uniformly distributed in the composite provide its rapid heating (tens of °Cmin(-1)) due to Neel magnetization relaxation. Required X-ray contrast of composite is achieved by addition of potassium iodide.
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