LDL-aferéza v léčbě familiárních hyperlipoproteinemií
[LDL-apheresis in the treatment familial hypercholesterolemia]
Jazyk čeština Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
25600044
PII: 50917
- MeSH
- HDL-cholesterol krev MeSH
- hyperlipoproteinemie typ II krev terapie MeSH
- LDL-cholesterol krev MeSH
- lidé MeSH
- separace krevních složek metody MeSH
- triglyceridy krev MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- HDL-cholesterol MeSH
- LDL-cholesterol MeSH
- triglyceridy MeSH
LDL-apheresis is an extracorporeal elimination technique, which specifically removes LDL-cholesterol from the circulation. There are six methods for the selective LDL-cholesterol removal these days. The main indications for LDL-apheresis are the diagnosis of homozygous familial hypercholesterolemia, heterozygous familial hypercholesterolemia which is refractory the standard care and intolerance of routine care, and also patients with lipoprotein(a) increase resistant to the farmacotherapy. There is still debate which LDL-cholesterolemia is indication for LDL-apheresis therapy, and the recommendation differs among various countries. Despite large randomized trials are missing, there are several good quality studies to conclude, that the beneficial cardiovascular effects of LDL-apheresis in severe hypercholesterolemia are important and beneficial.