OBJECTIVE: To compare image quality of different reconstruction techniques in submillisievert ultralow-dose CT colonography (CTC) and to correlate colonic findings with subsequent optical colonoscopy. METHODS: 58 patients underwent ultralow-dose CTC. The images were reconstructed with filtered back projection (FBP), hybrid iterative reconstruction (HIR) or model-based iterative reconstruction (MBIR) techniques. In each segment, endoluminal noise (expressed as standard deviation of endoluminal density) was measured and image quality was rated on a five-point Likert scale by two independent readers. Colonic lesions were evaluated in consensus and correlated with subsequent optical colonoscopy where possible. RESULTS: The estimated radiation dose was 0.41 ± 0.05 mSv for the supine and 0.42 ± 0.04 mSv for the prone acquisitions. In the endoluminal view, the image quality was rated better in HIR, whereas better scores were obtained in MBIR in the cross-sectional view, where the endoluminal noise was the lowest (p < 0.0001). Five (26%) polyps were not identified using both computer-aided detection and endoluminal inspection in FBP images vs only one (5%) in MBIR and none in HIR images. CONCLUSION: This study showed that in submillisievert ultralow-dose CTC, the image quality for the endoluminal view is better when HIR is used, whereas MBIR yields superior images for the cross-sectional view. The inferior quality of images reconstructed with FBP may result in decreased detection of colonic lesions. ADVANCES IN KNOWLEDGE: Radiation dose from CTC can be safely reduced <1 mSv for both positions when iterative reconstruction is used. MBIR provides better image quality in the cross-sectional view and HIR in the endoluminal view.

Department of Radiology 1st Faculty of Medicine of Charles University Prague Prague Czech Republic

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Sub-milliSievert ultralow-dose CT colonography with iterative model reconstruction technique