BACKGROUND/OBJECTIVE: Obesity is an alarming threat for all age groups, including children. Fat overconsumption is one of the factors that directly influences this pathology. Recent studies have suggested that a common variant in the CD36 gene, that is, single-nucleotide polymorphism (SNP) rs1761667-A allele, that reduces CD36 expression, associates with high oral fat detection thresholds in some obese subjects. The objective was to assess fatty acid sensitivity in relation to CD36 SNP in young lean and obese children. SUBJECTS/METHODS: We studied lingual detection thresholds for emulsions, containing oleic acid, in Algerian children (n=116, age=8±0.5 years) who were divided into two groups: obese (n=57; body mass index (BMI) z-score=2.513±0.490) and lean children (n=59; BMI z-score=-0.138±0.601) by alternative-forced choice method. To correlate the lipid taste perception thresholds with CD36 SNP, the children were genotyped for A/G SNP rs1761667 in 5'UTR region of CD36 by using PCR and restriction fragment length polymorphism. RESULTS: We noticed significantly higher CD36 A-allele frequency (P=0.036) in young obese children compared with leans. CD36 A-allele was associated with higher lipid taste perception thresholds than G-allele in obese children, but not in lean controls. Moreover, waist circumference was positively correlated with reduced fat taste sensitivity in these children. CONCLUSIONS: CD36 SNP A-allele, being present both in young lean and in obese children, is associated with high threshold for fatty acid taste sensitivity only in obese children.

] Institute of Animal Physiology and Genetics Academy of Science Brno Czech Republic [2] Laboratory of Neurobiology and Molecular Psychiatry Laboratory of Molecular Physiology Department of Biochemistry Faculty of Science Masaryk University Brno Czech Republic

] Laboratory of Neurobiology and Molecular Psychiatry Laboratory of Molecular Physiology Department of Biochemistry Faculty of Science Masaryk University Brno Czech Republic [2] Physiologie de la Nutrition and Toxicologie UMR U866 INSERM Université de Bourgogne Agro Sup Dijon France

Laborartoire de Biologie Cellulaire and Moléculaire Université de Constantine 1 Constantine Algérie

Physiologie de la Nutrition and Toxicologie UMR U866 INSERM Université de Bourgogne Agro Sup Dijon France

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