Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers
Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
PubMed
26556365
PubMed Central
PMC4663583
DOI
10.3390/nu7115455
PII: nu7115455
Knihovny.cz E-zdroje
- Klíčová slova
- CD36, adolescents, obesity, oleic acid, taste,
- MeSH
- alely MeSH
- antigeny CD36 genetika MeSH
- chuťová percepce MeSH
- chuťové pohárky MeSH
- chuťový práh * MeSH
- dieta MeSH
- dietní tuky * MeSH
- frekvence genu MeSH
- genotyp MeSH
- glykoproteiny genetika MeSH
- hubenost genetika MeSH
- index tělesné hmotnosti * MeSH
- jednonukleotidový polymorfismus * MeSH
- kyselina olejová MeSH
- lidé MeSH
- mladiství MeSH
- obezita etiologie genetika MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Alžírsko MeSH
- Názvy látek
- antigeny CD36 MeSH
- dietní tuky * MeSH
- glykoproteiny MeSH
- kyselina olejová MeSH
Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.
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