Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-α (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-α gene polymorphisms.

Department of Physiology and Functional Exploration Farhat Hached University Hospital Sousse Tunisia

Institute of Animal Physiology and Genetics Academy of Science Veveří 97 602 00Brno Czech Republic

Laboratory of Neurobiology and Molecular Psychiatry Laboratory of Molecular Physiology Department of Biochemistry Faculty of Science Masaryk University Kotlářská 2 611 37Brno Czech Republic

Physiologie de la Nutrition et Toxicologie UMR U866 INSERM Université de Bourgogne Agro Sup 6 Boulevard Gabriel Dijon21000 France

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