The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25822988
DOI
10.1017/s0007114515000343
PII: S0007114515000343
Knihovny.cz E-resources
- Keywords
- Genes,
- MeSH
- Alleles MeSH
- CD36 Antigens genetics MeSH
- Administration, Oral MeSH
- Taste genetics MeSH
- Taste Perception genetics MeSH
- Taste Buds physiology MeSH
- Dietary Fats * MeSH
- Adult MeSH
- Genotype MeSH
- Interleukin-6 blood MeSH
- Polymorphism, Single Nucleotide MeSH
- Oleic Acid chemistry MeSH
- Middle Aged MeSH
- Humans MeSH
- Obesity physiopathology MeSH
- Food Preferences MeSH
- Cluster Analysis MeSH
- Tumor Necrosis Factor-alpha genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Tunisia MeSH
- Names of Substances
- CD36 Antigens MeSH
- Dietary Fats * MeSH
- Interleukin-6 MeSH
- Oleic Acid MeSH
- Tumor Necrosis Factor-alpha MeSH
Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-α (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-α gene polymorphisms.
Department of Physiology and Functional Exploration Farhat Hached University Hospital Sousse Tunisia
Institute of Animal Physiology and Genetics Academy of Science Veveří 97 602 00Brno Czech Republic
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