Identification of large channels in cationic PEGylated cubosome nanoparticles by synchrotron radiation SAXS and Cryo-TEM imaging
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25820228
DOI
10.1039/c5sm00169b
Knihovny.cz E-resources
- MeSH
- X-Ray Diffraction MeSH
- Liquid Crystals chemistry MeSH
- Cations chemistry MeSH
- RNA, Small Interfering chemistry metabolism MeSH
- Scattering, Small Angle MeSH
- Nanoparticles chemistry ultrastructure MeSH
- Drug Carriers chemistry MeSH
- Polyethylene Glycols chemistry MeSH
- Porosity MeSH
- RNA Interference MeSH
- Synchrotrons MeSH
- Microscopy, Electron, Transmission MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cations MeSH
- RNA, Small Interfering MeSH
- Drug Carriers MeSH
- Polyethylene Glycols MeSH
Extra-large nanochannel formation in the internal structure of cationic cubosome nanoparticles results from the interplay between charge repulsion and steric stabilization of the lipid membrane interfaces and is evidenced by cryogenic transmission electron microscopy (Cryo-TEM) and synchrotron radiation small-angle X-ray scattering (SAXS). The swollen cubic symmetry of the lipid nanoparticles emerges through a shaping transition of onion bilayer vesicle intermediates containing a fusogenic nonlamellar lipid. Cationic amphiphile cubosome particles, thanks to the advantages of their liquid crystalline soft porous nanoarchitecture and capability for multi-drug nanoencapsulation, appear to be of interest for the design of mitochondrial targeting devices in anti-cancer therapies and as siRNA nanocarriers for gene silencing.
References provided by Crossref.org
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