Liposomal delivery systems for anti-cancer analogues of vitamin E
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
25861728
DOI
10.1016/j.jconrel.2015.04.003
PII: S0168-3659(15)00221-7
Knihovny.cz E-zdroje
- Klíčová slova
- Alpha-tocopheryl succinate, Analogues of vitamin E, Anti-cancer drugs, Apoptosis, Drug delivery systems, Drug targeting, Liposome, Nanomedicine,
- MeSH
- alfa-tokoferol aplikace a dávkování MeSH
- apoptóza účinky léků MeSH
- farmaceutická chemie MeSH
- lékové transportní systémy metody MeSH
- lidé MeSH
- lipidy chemie MeSH
- liposomy MeSH
- nádory farmakoterapie patologie MeSH
- protinádorové látky aplikace a dávkování chemie MeSH
- rozpustnost MeSH
- vitamin E aplikace a dávkování analogy a deriváty chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- alfa-tokoferol MeSH
- lipidy MeSH
- liposomy MeSH
- protinádorové látky MeSH
- vitamin E MeSH
Pro-apoptotic analogues of vitamin E (VE) exert selective anti-cancer effect on various animal cancer models. Neither suitable formulation of α-tocopheryl succinate (α-TOS), representative semi-synthetic VE analogue ester, nor suitable formulations of the other VE analogues for clinical application have been reported yet. The major factor limiting the use of VE analogues is their low solubility in aqueous solvents. Due to the hydrophobic character of VE analogues, liposomes are predetermined as suitable delivery system. Liposomal formulation prevents undesirable side effects of the drug, enhances the drug biocompatibility, and improves the drug therapeutic index. Liposomal formulations of VE analogues especially of α-TOS and α-tocopheryl ether linked acetic acid (α-TEA) have been developed. The anti-cancer effect of these liposomal VE analogues has been successfully demonstrated in pre-clinical models in vivo. Present achievements in: (i) preparation of liposomal formulations of VE analogues, (ii) physico-chemical characterization of these developed systems and (iii) testing of their biological activity such as induction of apoptosis and evaluation of anti-cancer effect are discussed in this review.
Department of Pharmacology and Immunotherapy Veterinary Research Institute Brno Czech Republic
Institute of Pharmaceutical Science King's College London London United Kingdom
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