Diffusion-weighted imaging using 3.0 T MRI as a possible biomarker of renal tumors
Language English Country Greece Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25862900
PII: 35/4/2351
Knihovny.cz E-resources
- Keywords
- Renal tumor, apparent diffusion coefficient, biomarker, diffusion weighted MRI, magnetic resonance imaging,
- MeSH
- Diffusion Magnetic Resonance Imaging * MeSH
- Adult MeSH
- Image Interpretation, Computer-Assisted MeSH
- Carcinoma, Renal Cell diagnosis diagnostic imaging pathology MeSH
- Contrast Media * chemistry MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Biomarkers, Tumor chemistry MeSH
- Kidney Neoplasms diagnosis diagnostic imaging pathology MeSH
- Adenoma, Oxyphilic diagnosis diagnostic imaging pathology MeSH
- Radiography MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Neoplasm Staging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Contrast Media * MeSH
- Biomarkers, Tumor MeSH
BACKGROUND/AIM: Diffusion-weighted imaging (DWI) allows for differentiation of benign from malignant tumors, histological tumor types and their grade. The aim of the study was to evaluate the capabilities of DWI using 3 Tesla Magnetic resonance imaging (3T MRI) in the preoperative assessment of renal tumors. PATIENTS AND METHODS: This retrospective study included 143 tumors in 139 patients (130 malignant tumors and 13 benign tumors) that were examined using DWI with b values of 50, 400 and 800 s/mm(2). In all tumors, the lowest value of apparent diffusion coefficient (ADC) in the solid tissue was measured and correlated with the histological finding. RESULTS: A significant difference between ADCs of malignant and benign tumors was found (p<0.001). Comparison of the most common malignant and benign tumors clear-cell renal carcinoma (CCRCC) grade I and oncocytoma resulted in a difference of borderline significance with a marked overlap (p=0.046). By assessing the histological types of malignant tumors, we detected a significant difference between CCRCC and all other histological types (p=0.048 for chromophobe (CH) RCC, p=0.002 for papillary (P) RCC and p=0.002 for urothelial carcinoma (UC)). Mutual differentiation of other types of carcinomas was not feasible (p=1.0 in all cases). The differences between low-grade (grade I+II) and high-grade (grade III+IV) CCRCC was significant (p<0.001). A significant difference was found even between CCRCC grade I and others (p=0.01 for grade II, p<0.001 for grade III+IV, respectively). CONCLUSION: DWI may contribute in distinguishing CCRCC from other histological types and to determinits grade. The method has certain potential for distinguishing benign from malignant tumors; however, differentiation of the most frequently represented types, CCRCC grade I and oncocytoma, remains difficult.
