Changes of the complement system and rheological indicators after therapy with rheohemapheresis
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25936318
DOI
10.1016/j.atherosclerosissup.2015.02.009
PII: S1567-5688(15)00010-0
Knihovny.cz E-zdroje
- Klíčová slova
- Age-related macular degeneration, Complement, Rheology, Rheopheresis, Sudden sensorial hearing loss,
- MeSH
- aktivace komplementu * MeSH
- komplement - faktor H metabolismus MeSH
- komplement metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- makulární degenerace krev diagnóza imunologie terapie MeSH
- náhlá nedoslýchavost krev diagnóza imunologie terapie MeSH
- percepční nedoslýchavost krev diagnóza imunologie terapie MeSH
- reologie krve * MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- separace krevních složek metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- CFH protein, human MeSH Prohlížeč
- komplement - faktor H MeSH
- komplement MeSH
INTRODUCTION: In the last 10 years, many studies have been published on the role of the complement system in microcirculation disorders. However, as for the changes of complement components after rheohemapheresis, there is still a lack of detailed data in the literature. Complement changes may play an important role in pathogenesis of some microcirculation disorders, such as age-related macular degeneration and acute hearing loss. The objective of this study was to investigate the effect of rheohemapheresis on the basic complement pathways. PATIENTS AND METHODS: 32 patients were treated with rheohemapheresis, including 16 patients (10 men and 6 women) for age-related macular degeneration (AMD), mean age 69.7 ± 6.06 years (range 62-87 years) and 16 patients (11 men and 5 women) aged 56.4 ± 11.5 (range 34-73 years) for acute hearing loss. RESULTS: Rheohemapheresis led to a significant drop of all three complement-activation pathways in both groups of patients. Moreover, complement factor H was also reduced. CONCLUSION: The observed reduction in all three basic complement activation pathways after rheohemapheresis could be clinically important. The search continues both to find substances which influence complement systems and to develop more effective new drugs that require less frequent administration and that provide improved intraocular therapy for AMD patients.
Citace poskytuje Crossref.org
Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss