Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- Apoptosis, Bnip3L, PCR arrays, caspase-12, hair follicles,
- MeSH
- Apoptosis physiology MeSH
- Caspase 12 biosynthesis MeSH
- Skin cytology metabolism MeSH
- Membrane Proteins biosynthesis MeSH
- Mitochondrial Proteins biosynthesis MeSH
- Mice MeSH
- Gene Expression Regulation physiology MeSH
- Hair Follicle cytology metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Casp12 protein, mouse MeSH Browser
- Caspase 12 MeSH
- Membrane Proteins MeSH
- Mitochondrial Proteins MeSH
- Nix protein, mouse MeSH Browser
Hair follicles undergo repetitive stages of cell proliferation and programmed cell death. The catagen stage of physiological apoptosis is connected with dynamic changes in morphology and alterations in gene expression. However, hair follicle apoptosis must be in balance with events in surrounding tissues, such as keratinocyte cornification, to maintain complex skin homeostasis. Several pro- and anti-apoptotic molecules in the skin have been reported but mainly in pathological states. In this investigation, apoptosis-related gene expression was examined during the first catagen stage of mouse hair follicle development by PCR arrays under physiological conditions. Postnatal stages P15 and P17, representing early and late catagen stages, were evaluated relatively to stage P6, representing the hair follicle growing phase, to demonstrate dynamics of gene activation during the catagen. Several statistically significant alterations were observed at P15 and particularly at P17. Bnip3L and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
References provided by Crossref.org
Exploring caspase functions in mouse models
Making the head: Caspases in life and death
Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue