Steroid hormones in prediction of normal pressure hydrocephalus
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25976421
DOI
10.1016/j.jsbmb.2015.05.004
PII: S0960-0760(15)00128-4
Knihovny.cz E-resources
- Keywords
- Aldosterone, Cerebrospinal fluid, Neuroactive steroids, Normal pressure hydrocephalus, Prediction,
- MeSH
- Aldosterone cerebrospinal fluid MeSH
- Chromatography, Liquid MeSH
- Dehydroepiandrosterone analogs & derivatives cerebrospinal fluid MeSH
- Mass Spectrometry MeSH
- Adrenal Cortex Hormones cerebrospinal fluid MeSH
- Hydrocortisone cerebrospinal fluid MeSH
- Cortisone cerebrospinal fluid MeSH
- Humans MeSH
- Hydrocephalus, Normal Pressure cerebrospinal fluid diagnosis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Aldosterone MeSH
- Dehydroepiandrosterone MeSH
- Adrenal Cortex Hormones MeSH
- Hydrocortisone MeSH
- Cortisone MeSH
Normal pressure hydrocephalus (NPH) is a treatable neurological disorder affecting elderly people with the prevalence increasing with age. NPH is caused by abnormal cerebrospinal fluid (CSF) reabsorption and manifested as a balance impairment, urinary incontinence and dementia development. These symptoms are potentially reversible if recognized early. Diagnosis of NPH is difficult and can be easily mistaken for other neurodegenerative disorders, which makes NPH one of the major misdiagnosed diseases worldwide. The aim of the study was to find out the appropriate combination of indicators, based on CSF steroids, which would contribute to a clearer NPH diagnosis. The levels of CSF cortisol, cortisone, dehydroepiandrosterone (DHEA), 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, 16α-OH-DHEA and aldosterone (all LC-MS/MS) were determined in our patients (n=30; NPH, 65-80 years) and controls (n=10; 65-80 years). The model of orthogonal projections to latent structures (OPLS) was constructed to predict NPH. Cortisone, 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, aldosterone, 7α-OH-DHEA /DHEA, 7-oxo-DHEA/7α-OH-DHEA, 7β-OH-DHEA/7-oxo-DHEA and 16α-OH-DHEA/DHEA in the CSF were identified as the key predictors and the model discriminated patients from controls with 100% sensitivity and 100% specificity. The suggested model would contribute to early and accurate NPH diagnosis, enabling promptly treatment of the disease.
References provided by Crossref.org
Normal pressure hydrocephalus-an overview of pathophysiological mechanisms and diagnostic procedures
Steroid diagnostics of 21st century in the light of their new roles and analytical tools
