Steroid hormones in prediction of normal pressure hydrocephalus
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25976421
DOI
10.1016/j.jsbmb.2015.05.004
PII: S0960-0760(15)00128-4
Knihovny.cz E-zdroje
- Klíčová slova
- Aldosterone, Cerebrospinal fluid, Neuroactive steroids, Normal pressure hydrocephalus, Prediction,
- MeSH
- aldosteron mozkomíšní mok MeSH
- chromatografie kapalinová MeSH
- dehydroepiandrosteron analogy a deriváty mozkomíšní mok MeSH
- hmotnostní spektrometrie MeSH
- hormony kůry nadledvin mozkomíšní mok MeSH
- hydrokortison mozkomíšní mok MeSH
- kortison mozkomíšní mok MeSH
- lidé MeSH
- normotenzní hydrocefalus mozkomíšní mok diagnóza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- aldosteron MeSH
- dehydroepiandrosteron MeSH
- hormony kůry nadledvin MeSH
- hydrokortison MeSH
- kortison MeSH
Normal pressure hydrocephalus (NPH) is a treatable neurological disorder affecting elderly people with the prevalence increasing with age. NPH is caused by abnormal cerebrospinal fluid (CSF) reabsorption and manifested as a balance impairment, urinary incontinence and dementia development. These symptoms are potentially reversible if recognized early. Diagnosis of NPH is difficult and can be easily mistaken for other neurodegenerative disorders, which makes NPH one of the major misdiagnosed diseases worldwide. The aim of the study was to find out the appropriate combination of indicators, based on CSF steroids, which would contribute to a clearer NPH diagnosis. The levels of CSF cortisol, cortisone, dehydroepiandrosterone (DHEA), 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, 16α-OH-DHEA and aldosterone (all LC-MS/MS) were determined in our patients (n=30; NPH, 65-80 years) and controls (n=10; 65-80 years). The model of orthogonal projections to latent structures (OPLS) was constructed to predict NPH. Cortisone, 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, aldosterone, 7α-OH-DHEA /DHEA, 7-oxo-DHEA/7α-OH-DHEA, 7β-OH-DHEA/7-oxo-DHEA and 16α-OH-DHEA/DHEA in the CSF were identified as the key predictors and the model discriminated patients from controls with 100% sensitivity and 100% specificity. The suggested model would contribute to early and accurate NPH diagnosis, enabling promptly treatment of the disease.
Citace poskytuje Crossref.org
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