Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26201459
DOI
10.1017/s0950268815001521
PII: S0950268815001521
Knihovny.cz E-resources
- Keywords
- Community-acquired pneumonia, Panton–Valentine leukocidin, Staphylococcus aureus, necrotizing pneumonia, septic shock,
- MeSH
- Pneumonia, Bacterial drug therapy microbiology mortality MeSH
- Bacterial Toxins biosynthesis MeSH
- Adult MeSH
- Exotoxins biosynthesis MeSH
- Genetic Variation MeSH
- Community-Acquired Infections microbiology MeSH
- Infant MeSH
- Leukocidins biosynthesis MeSH
- Middle Aged MeSH
- Humans MeSH
- Methicillin-Resistant Staphylococcus aureus genetics metabolism MeSH
- Adolescent MeSH
- Young Adult MeSH
- Necrosis microbiology MeSH
- Lung pathology MeSH
- Prognosis MeSH
- Prospective Studies MeSH
- Seasons MeSH
- Shock, Septic microbiology MeSH
- Staphylococcus aureus MeSH
- Streptococcal Infections drug therapy microbiology mortality MeSH
- Check Tag
- Adult MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Bacterial Toxins MeSH
- Exotoxins MeSH
- Leukocidins MeSH
- Panton-Valentine leukocidin MeSH Browser
A prospective study (2007-2013) was undertaken to investigate clinical features and prognostic factors of necrotizing pneumonia caused by Staphylococcus aureus producing Panton-Valentine leukocidin (PVL) in the Czech Republic. Twelve cases of necrotizing pneumonia were detected in 12 patients (median age 25 years) without severe underlying disease. Eight cases occurred in December and January and the accumulation of cases in the winter months preceding the influenza season was statistically significant (P < 0·001). The course of pneumonia was very rapid, leading to early sepsis and/or septic shock in all but one patient. Seven patients died and mortality was fourfold higher in those patients presenting with primary pneumonia than with pneumonia complicating other staphylococcal/pyogenic infection elsewhere in the body. The S. aureus isolates displayed considerable genetic variability and were assigned to five lineages CC8 (n = 3), CC15 (n = 2), CC30 (n = 2), CC80 (n = 1), and CC121 (n = 3) and one was a singleton of ST154 (n = 1), all were reported to be associated with community-acquired infection. Four strains were methicillin resistant. The high case-fatality rate can only be reduced by improving the speed of diagnosis and a rapid test to detect S. aureus in the airways is needed.
Department of Experimental Biology Faculty of Science Masaryk University Brno Czech Republic
Department of Infectious Diseases 3rd Faculty of Medicine Charles University Prague Czech Republic
Reference Laboratory for Staphylococci National Institute of Public Health Prague Czech Republic
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