Pregnancy Outcome in Patients with Common Variable Immunodeficiency
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26280892
DOI
10.1007/s10875-015-0188-7
PII: 10.1007/s10875-015-0188-7
Knihovny.cz E-resources
- Keywords
- CVID, fertility, pregnancy, replacement therapy,
- MeSH
- Common Variable Immunodeficiency complications immunology MeSH
- Uterine Hemorrhage etiology MeSH
- Child MeSH
- Adult MeSH
- Immunoglobulin A genetics MeSH
- Cohort Studies MeSH
- Pregnancy Complications immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Obstetric Labor, Premature etiology MeSH
- Child, Preschool MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Pregnancy immunology MeSH
- Pregnancy Outcome MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Child, Preschool MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Pregnancy immunology MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunoglobulin A MeSH
PURPOSE: The aim of our retrospective study was to clarify fertility, pregnancy complications and outcomes in common variable immunodeficiency (CVID) females. METHODS: Retrospective data were obtained from three Czech referral centres. The data were compared with data obtained from the Czech National Registry of Reproduction Health. RESULTS: Our cohort of patients comprised 54 women with 115 pregnancies; 88 pregnancies in 50 females were finished with live births (77 %). In only 8 women (15%) was the diagnosis of CVID established before the first pregnancy. Replacement immunoglobulin therapy was performed in 10 patients without any moderate or severe adverse effects. Compared with the Czech population, the CVID patients suffered significantly more frequently from the threat of preterm labour (p < 0.0001), vaginal bleeding (p = 0.0001), eclampsia/preeclampsia (p = 0.009) and a higher number of stillbirths (p < 0.0001). Furthermore, the frequency of babies with low birth weight (less than 2500 g) born to the CVID patients was increased compared with the normal population (p < 0.0001). Serum IgG, IgA and IgM determination was done in 57 children of 50 mothers showing 13 cases of IgA deficiency (23%). There was no significant difference among the non-symptomatic, symptomatic untreated and symptomatic treated females in any of the determined gynaecological complications. The number of unsuccessful pregnancies was higher in the symptomatic untreated women. CONCLUSIONS: Fertility in CVID patients is not decreased, and their pregnancies could be considered more risky compared with those of the general population.
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J Clin Immunol. 2007 May;27(3):308-16 PubMed
Br J Obstet Gynaecol. 1993 Dec;100(12):1138-40 PubMed
Lancet. 1966 Nov 26;2(7474):1152-5 PubMed
BMJ Case Rep. 2012 Dec 17;2012:null PubMed
Clin Exp Immunol. 1980 Aug;41(2):303-8 PubMed
Am J Med. 1984 Mar 30;76(3A):73-7 PubMed
Am J Reprod Immunol. 1996 Nov;36(5):248-55 PubMed
Clin Immunol. 1999 Dec;93(3):190-7 PubMed
JAMA. 1982 May 28;247(20):2824-5 PubMed
Eur J Pediatr. 2012 Jan;171(1):121-4 PubMed
Am J Hematol. 1986 Mar;21(3):327-9 PubMed
Arch Gynecol Obstet. 1996;258(3):155-9 PubMed
Nature. 1966 Jun 4;210(5040):1070-1 PubMed
Tohoku J Exp Med. 1986 Aug;149(4):359-65 PubMed
J Clin Immunol. 2001 Mar;21(2):150-4 PubMed
Arch Dis Child. 1973 Aug;48(8):646-8 PubMed
Int Arch Allergy Immunol. 2000 Oct;123(2):177-80 PubMed
Ann Allergy Asthma Immunol. 2012 Jun;108(6):464-5 PubMed
J Lab Clin Med. 1959 Mar;53(3):331-57 PubMed
Am J Hum Genet. 1999 Apr;64(4):1096-109 PubMed
J Clin Immunol. 2015 Feb;35(2):125-34 PubMed
J Clin Invest. 1959 Mar;38(3):579-86 PubMed
Blood. 2012 Feb 16;119(7):1650-7 PubMed
Blut. 1990 Mar;60(3):198-201 PubMed
J Perinatol. 1994 Mar-Apr;14(2):114-7 PubMed
