Transcranial sonography of brainstem structures in panic disorder
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
26371456
DOI
10.1016/j.pscychresns.2015.09.010
PII: S0925-4927(15)30088-3
Knihovny.cz E-zdroje
- Klíčová slova
- Brainstem raphe, Panic disorder, Transcranial sonography,
- MeSH
- depresivní poruchy komplikace diagnostické zobrazování MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mozkový kmen diagnostické zobrazování MeSH
- nuclei raphe diagnostické zobrazování MeSH
- panická porucha komplikace diagnostické zobrazování MeSH
- senzitivita a specificita MeSH
- substantia nigra diagnostické zobrazování MeSH
- ultrasonografie dopplerovská transkraniální metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Panic disorder has been associated with altered serotonin metabolism in the brainstem raphe. The aim of study was to evaluate the BR echogenicity on transcranial sonography (TCS) in panic disorder. A total of 96 healthy volunteers were enrolled in the "derivation" cohort, and 26 healthy volunteers and 26 panic disorder patients were enrolled in the "validation" cohort. TCS echogenicity of brainstem raphe and substantia nigra was assessed on anonymized images visually and by means of digitized image analysis. Significantly reduced brainstem raphe echogenicity was detected more frequently in panic disorder patients than in controls using both visual (68% vs. 31%) and digitized image analysis (52% vs. 12%). The optimal cut-off value of digitized brainstem raphe echogenicity indicated the diagnosis of panic disorder with a sensitivity of 64% and a specificity of 73%, and corresponded to the 30th percentile in the derivation cohort. Reduced brainstem raphe echogenicity was associated with shorter treatment duration, and, by trend, lower severity of anxiety. No relationship was found between echogenicity of brainstem raphe or substantia nigra and age, gender, severity of panic disorder, or severity of depression. Patients with panic disorder exhibit changes of brainstem raphe on TCS suggesting an alteration of the central serotonergic system.
Department of Neurology University of Rostock Rostock Germany
Department of Psychiatry University Hospital Ostrava Czech Republic
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