MicroRNAs in urine are not biomarkers of multiple myeloma

. 2015 Sep 23 ; 14 () : 16. [epub] 20150923

Jazyk angličtina Země Anglie, Velká Británie Médium electronic

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid26399230
Odkazy

PubMed 26399230
PubMed Central PMC4581458
DOI 10.1186/s12952-015-0035-7
PII: 10.1186/s12952-015-0035-7
Knihovny.cz E-zdroje

BACKGROUND: In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. RESULTS: Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA (p < 0.05); for further validation, we chose 8 of them. Nevertheless, only differences in expression levels of miR-22-3p remained close to statistical significance. CONCLUSIONS: Our preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma.

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