MicroRNAs in urine are not biomarkers of multiple myeloma
Jazyk angličtina Země Anglie, Velká Británie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26399230
PubMed Central
PMC4581458
DOI
10.1186/s12952-015-0035-7
PII: 10.1186/s12952-015-0035-7
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikro RNA genetika moč MeSH
- mnohočetný myelom diagnóza genetika moč MeSH
- nádorové biomarkery moč MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stanovení celkové genové exprese metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- mikro RNA MeSH
- nádorové biomarkery MeSH
BACKGROUND: In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. RESULTS: Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA (p < 0.05); for further validation, we chose 8 of them. Nevertheless, only differences in expression levels of miR-22-3p remained close to statistical significance. CONCLUSIONS: Our preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma.
Central European Institute of Technology Masaryk University Brno Czech Republic
Department of Clinical Hematology University Hospital Brno Brno Czech Republic
Department of Hematology and Oncology Kantonsspital St Gallen St Gallen Switzerland
Department of Internal Medicine Hematooncology University Hospital Brno Brno Czech Republic
Department of urologic oncology Masaryk Memorial Cancer Institute Brno Czech Republic
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