Calretinin and parvalbumin immunoreactive interneurons in the retrosplenial cortex of the rat brain: Qualitative and quantitative analyses
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26449685
DOI
10.1016/j.brainres.2015.09.031
PII: S0006-8993(15)00729-5
Knihovny.cz E-zdroje
- Klíčová slova
- Calcium-binding proteins, Calretinin, Interneurons, Parvalbumin, Perirhinal cortex, Retrosplenial cortex,
- MeSH
- analýza rozptylu MeSH
- denzitometrie MeSH
- interneurony metabolismus MeSH
- kalbindin 2 metabolismus MeSH
- krysa rodu Rattus MeSH
- mozková kůra cytologie MeSH
- parvalbuminy metabolismus MeSH
- potkani Wistar MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- kalbindin 2 MeSH
- parvalbuminy MeSH
The retrosplenial cortex (RSC) is a mesocortical region broadly involved with memory and navigation. It shares many characteristics with the perirhinal cortex (PRC), both of which appear to be significantly involved in the spreading of epileptic activity. We hypothesized that RSC possesses an interneuronal composition similar to that of PRC. To prove the hypothesis we studied the general pattern of calretinin (CR) and parvalbumin (PV) immunoreactivity in the RSC of the rat brain, its optical density as well as the morphological features and density of CR- and PV-immunoreactive (CR+ and PV+) interneurons. We also analyzed the overall neuronal density on Nissl-stained sections in RSC. Finally, we compared our results with our earlier analysis of PRC (Barinka et al., 2012). Compared to PRC, RSC was observed to have a higher intensity of PV staining and lower intensity of CR staining of neuropil. Vertically-oriented bipolar neurons were the most common morphological type among CR+ neurons. The staining pattern did not allow for a similarly detailed analysis of somatodendritic morphology of PV+ neurons. RSC possessed lower absolute (i.e., neurons/mm(3)) and relative (i.e., percentage of the overall neuronal population) densities of CR+ neurons and similar absolute and lower relative densities of PV+ neurons relative to PRC. CR: PV neuronal ratio in RSC (1:2 in area 29 and 1:2.2 in area 30) differed from PRC (1:1.2 in area 35 and 1:1.7 in area 36). In conclusion, RSC, although similar in many aspects to PRC, differs strikingly in the interneuronal composition relative to PRC.
Department of Anatomy Charles University Prague 2nd Faculty of Medicine Prague Czech Republic
Department of Neurology University of Regensburg Bezirksklinikum Regensburg Regensburg Germany
Institute of Physiology Academy of Sciences of the Czech Republic Prague Czech Republic
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