Here we present an overview of what is known about endogenous plant compounds that act as inhibitors of hormonal transport processes in plants, about their identity and mechanism of action. We have also summarized commonly and less commonly used compounds of non-plant origin and synthetic drugs that show at least partial 'specificity' to transport or transporters of particular phytohormones. Our main attention is focused on the inhibitors of auxin transport. The urgent need to understand precisely the molecular mechanism of action of these inhibitors is highlighted.

Institute of Experimental Botany The Czech Academy of Sciences Rozvojová 263 165 02 Prague 6 Czech Republic

See more in PubMed

New Phytol. 2014 Jul;203(2):362-77 PubMed

Trends Plant Sci. 2001 Nov;6(11):535-42 PubMed

Plant Cell. 1991 Jul;3(7):677-684 PubMed

Mol Biol Cell. 2013 Feb;24(4):510-20 PubMed

Nature. 2005 Jun 30;435(7046):1251-6 PubMed

Planta. 1992 Mar;186(4):618-25 PubMed

Planta. 1987 Oct;172(2):252-64 PubMed

Plant Physiol. 1972 Sep;50(3):322-7 PubMed

Plant J. 2011 Sep;67(5):885-94 PubMed

Plant Cell. 2014 Jul;26(7):3062-76 PubMed

Dev Cell. 2011 Oct 18;21(4):796-804 PubMed

J Exp Bot. 2009;60(11):3075-83 PubMed

J Biol Chem. 2010 Jul 23;285(30):23309-17 PubMed

Curr Biol. 2009 Mar 10;19(5):391-7 PubMed

Science. 1996 Aug 16;273(5277):948-50 PubMed

Nature. 2001 Sep 27;413(6854):425-8 PubMed

Science. 1983 Feb 4;219(4584):493-5 PubMed

Cell. 2003 Jan 24;112(2):219-30 PubMed

Curr Biol. 2003 Aug 19;13(16):1378-87 PubMed

J Biol Chem. 1992 Feb 5;267(4):2157-63 PubMed

Nat Cell Biol. 2008 Feb;10(2):237-44 PubMed

Mol Plant. 2010 Jan;3(1):2-20 PubMed

Curr Opin Plant Biol. 2003 Feb;6(1):7-12 PubMed

Cell Mol Life Sci. 2008 Nov;65(21):3433-45 PubMed

Plant Cell. 2000 Feb;12(2):291-300 PubMed

Chem Biol. 2007 Dec;14(12):1366-76 PubMed

Science. 1988 Jul 15;241(4863):346-9 PubMed

J Biol Chem. 2006 Oct 13;281(41):30603-12 PubMed

J Exp Bot. 2015 Feb;66(4):1113-21 PubMed

Plant Cell Physiol. 2014 Apr;55(4):737-49 PubMed

Nature. 2012 Mar 07;483(7389):341-4 PubMed

Plant J. 2001 Feb;25(4):399-406 PubMed

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4902-7 PubMed

New Phytol. 2013 Dec;200(4):1034-48 PubMed

Plant Cell. 2013 Oct;25(10):3858-70 PubMed

Planta Med. 2015 Apr;81(6):474-87 PubMed

Planta. 1996 Apr;198(4):532-541 PubMed

J Biol Chem. 2008 Nov 7;283(45):31218-26 PubMed

J Exp Bot. 2010 Aug;61(13):3589-98 PubMed

Plant Sci. 2012 Nov;196:67-76 PubMed

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4489-94 PubMed

PLoS Genet. 2013 May;9(5):e1003540 PubMed

Planta. 2000 Mar;210(4):580-8 PubMed

Plant Physiol. 2002 Mar;128(3):935-50 PubMed

Cell. 2010 Oct 1;143(1):111-21 PubMed

Plant Cell. 2011 May;23(5):1920-31 PubMed

Cell Biol Int Rep. 1984 Jul;8(7):519-35 PubMed

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7150-5 PubMed

Plant Physiol. 1976 Jun;57(6):839-41 PubMed

Curr Biol. 2007 Dec 4;17(23):2047-53 PubMed

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17812-7 PubMed

Mol Plant. 2008 Nov;1(6):1056-66 PubMed

Plant J. 1997 Sep;12 (3):583-95 PubMed

Phytochemistry. 2003 Jan;62(1):1-4 PubMed

J Exp Bot. 2015 Aug;66(16):4971-82 PubMed

Plant Cell. 2012 Jul;24(7):3074-86 PubMed

New Phytol. 2014 Jan;201(2):466-75 PubMed

Plant J. 2006 Dec;48(5):757-70 PubMed

Plant Cell. 2005 Jan;17(1):132-48 PubMed

Nature. 2001 Jun 14;411(6839):843-7 PubMed

Curr Biol. 2007 Mar 20;17(6):520-7 PubMed

Plant J. 2009 Jan;57(1):27-44 PubMed

Plant Cell. 2006 Nov;18(11):3171-81 PubMed

Development. 2010 Oct;137(19):3245-55 PubMed

J Biol Chem. 2003 Apr 4;278(14 ):12022-8 PubMed

Plant Physiol. 2003 Jan;131(1):254-63 PubMed

Plant J. 1998 Feb;13(3):291-301 PubMed

Cell Res. 1999 Mar;9(1):27-35 PubMed

Nature. 2002 Feb 14;415(6873):806-9 PubMed

Annu Rev Plant Biol. 2008;59:443-65 PubMed

Biochem J. 2014 Jun 1;460(2):177-85 PubMed

Plant J. 2013 Mar;73(5):709-19 PubMed

Plant Cell. 1993 Jun;5(6):621-630 PubMed

BMC Plant Biol. 2015 Nov 05;15:272 PubMed

Plant Cell Physiol. 2014 Apr;55(4):750-63 PubMed

J Cell Biol. 1995 Sep;130(6):1307-18 PubMed

Plant Cell. 2004 Jul;16(7):1898-911 PubMed

J Biol Chem. 2008 Aug 1;283(31):21817-26 PubMed

Ann Oncol. 1994;5 Suppl 6:S3-6 PubMed

Plant Physiol. 1980 Dec;66(6):1074-8 PubMed

Curr Biol. 2015 Mar 2;25(5):647-55 PubMed

Plant Physiol. 2002 Nov;130(3):1102-8 PubMed

Plant Cell. 2009 Jun;21(6):1659-68 PubMed

Plant Physiol. 2001 Feb;125(2):990-1000 PubMed

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1554-9 PubMed

Plant Cell. 2002 Jan;14(1):71-86 PubMed

Science. 1988 Nov 11;242(4880):933-5 PubMed

Science. 2006 May 12;312(5775):914-8 PubMed

Plant Physiol. 1980 Dec;66(6):1190-5 PubMed

Plant J. 2005 Oct;44(2):179-94 PubMed

J Biol Chem. 2011 Jan 21;286(3):2354-64 PubMed

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8464-9 PubMed

Planta. 1974 Jun;118(2):101-21 PubMed

Nature. 2007 Jul 26;448(7152):488-92 PubMed

Plant Physiol. 2005 May;138(1):196-206 PubMed

Plant Cell. 2010 Feb;22(2):364-75 PubMed

Plant Physiol. 1996 Jun;111(2):427-432 PubMed

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17850-5 PubMed

Plant Physiol. 2001 Jun;126(2):536-48 PubMed

Plant Cell. 2009 Dec;21(12):3839-49 PubMed

Science. 1998 Dec 18;282(5397):2226-30 PubMed

Plant Cell. 1994 Dec;6(12):1941-53 PubMed

Plant Cell. 2004 May;16(5):1191-205 PubMed

Science. 1999 Oct 8;286(5438):316-8 PubMed

Plant Physiol. 1996 Sep;112(1):421-432 PubMed

Development. 2009 Aug;136(16):2675-88 PubMed

Curr Biol. 2008 Apr 8;18(7):526-31 PubMed

Plant Cell. 2006 Jun;18(6):1396-411 PubMed

Plant Physiol. 2014 Apr;164(4):1587-92 PubMed

J Am Chem Soc. 1971 May 5;93(9):2325-7 PubMed

Plant Physiol. 2009 Aug;150(4):2081-91 PubMed

Plant J. 2003 Apr;34(1):13-26 PubMed

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E806-15 PubMed

Plant Cell. 2001 Nov;13(11):2441-54 PubMed

Phytochemistry. 1992 Jul;31(7):2435-8 PubMed

Plant Cell. 2010 Sep;22(9):2999-3019 PubMed

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2355-60 PubMed

Curr Biol. 2013 Dec 16;23(24):2500-5 PubMed

Lessons Learned from the Studies of Roots Shaded from Direct Root Illumination