Smoking impairs and circulating stem cells favour the protective effect of the T allele of the connexin37 gene in ischemic heart disease--A multinational study
Language English Country Ireland Media print-electronic
Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
PubMed
26588185
DOI
10.1016/j.atherosclerosis.2015.11.007
PII: S0021-9150(15)30203-3
Knihovny.cz E-resources
- Keywords
- Cardiovascular risk factors, Connexin37 gene, Endothelial progenitor cells, Ischemic heart disease, Sex, Stem cells,
- MeSH
- Alleles MeSH
- DNA genetics MeSH
- Adult MeSH
- Endothelial Progenitor Cells cytology MeSH
- Genetic Predisposition to Disease * MeSH
- Genotype MeSH
- Heterozygote MeSH
- Myocardial Ischemia genetics metabolism pathology MeSH
- Polymorphism, Single Nucleotide * MeSH
- Stem Cells cytology MeSH
- Connexins genetics metabolism MeSH
- Smoking adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Polymerase Chain Reaction MeSH
- Gap Junction alpha-4 Protein MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA MeSH
- Connexins MeSH
BACKGROUND: The connexin 37 (Cx37) gene is considered to be a candidate gene for ischemic heart disease (IHD). We analyzed the association between the C1019 > T (Pro319 > Ser) variant of the Cx37 gene and IHD in patients in the Czech Republic, Croatia, Hungary and Romania with regard to the presence/absence of selected cardiovascular risk factors (RF). In a complementary study, we analyzed the association between the Cx37 gene and circulating stem and endothelial progenitor cells in healthy women. METHODS: The study population comprised 2396 patients (663 women) with IHD. The control population comprised 2476 subjects (1, 337 women). Additionally, in 662 healthy women, the association between the Cx37 gene and circulating stem and endothelial progenitor cells was analyzed. RESULTS: The strongest protective effect of the Cx37 T allele was detected in non-smoking patients without diabetes mellitus and hypertension (OR 0.610, 95% CI 0.377-0.990); a similar effect was found in non-smoking men (OR 0.781, 95% CI 0.628-0.971); weaker effect was found in non-smoking women (OR 0.768, 95% CI 0.560-1.050). In non-smoking healthy women, stem cells were significantly higher in TT than in CT and CC carriers (p for trend 0.011). Additionally, non-smoking TT carriers had significantly higher number of stem cells than past and current smoking TT carriers (p for trend = 0.006); no such trend was found in CT and CC carriers. CONCLUSIONS: The protective effect of the T allele of the Cx37 gene might be strongly modified by smoking; in women, this effect could be mediated through stem cells.
Department of Cardiovascular Disease and Intensive Care Osijek University Hospital Osijek Croatia
Department of Medical Biology and Genetics Faculty of Medicine University of Osijek Osijek Croatia
Emergency Clinical Hospital of Bucharest Cardiology Dept Romania
Medicine Statistic Unit Institute of Clinical and Experimental Medicine Prague Czech Republic
Regional Cooperation for Health Science and Technology Association Debrecen Hungary
References provided by Crossref.org
The role of connexin 37 polymorphism in spontaneous abortion
