Effect of HPV on tumor expression levels of the most commonly used markers in HNSCC
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články
PubMed
26666815
DOI
10.1007/s13277-015-4569-6
PII: 10.1007/s13277-015-4569-6
Knihovny.cz E-zdroje
- Klíčová slova
- Head and neck cancer, Human papillomavirus, Kaplan-Meier analysis, Tumor markers,
- MeSH
- DNA virů genetika MeSH
- dospělí MeSH
- infekce papilomavirem komplikace virologie MeSH
- kvantitativní polymerázová řetězová reakce MeSH
- lidé středního věku MeSH
- lidé MeSH
- messenger RNA genetika MeSH
- míra přežití MeSH
- nádorové biomarkery genetika MeSH
- nádory hlavy a krku etiologie patologie MeSH
- následné studie MeSH
- Papillomaviridae genetika MeSH
- polymerázová řetězová reakce s reverzní transkripcí MeSH
- prognóza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- spinocelulární karcinom etiologie patologie MeSH
- staging nádorů MeSH
- stanovení celkové genové exprese MeSH
- studie případů a kontrol MeSH
- stupeň nádoru MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- DNA virů MeSH
- messenger RNA MeSH
- nádorové biomarkery MeSH
Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+). Kaplan-Meier analysis was done to determine the relevance of these selected markers for HNSCC prognosis. In conclusion, our study confirms the impact of HPV infection on commonly studied HNSCC markers MT2A, MMP9, FLT1, VEGFA, and POU5F that were more highly expressed in HPV-negative HNSCC patients and also shows the relevance of studied markers in HPV-positive and HPV-negative HNSCC patients.
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