Associations of polymorphisms in bovine DGAT1, FABP4, FASN, and PPARGC1A genes with intramuscular fat content and the fatty acid composition of muscle and subcutaneous fat in Fleckvieh bulls
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26720887
DOI
10.1016/j.meatsci.2015.12.004
PII: S0309-1740(15)30142-X
Knihovny.cz E-resources
- Keywords
- Adipose tissue, Cattle, Fatty acid, Gene polymorphism,
- MeSH
- Alleles MeSH
- Atherosclerosis MeSH
- Diacylglycerol O-Acyltransferase genetics metabolism MeSH
- Species Specificity MeSH
- Phenotype * MeSH
- Genotype * MeSH
- Polymorphism, Single Nucleotide MeSH
- Humans MeSH
- Meat analysis MeSH
- Fatty Acids metabolism MeSH
- Subcutaneous Fat metabolism MeSH
- Polymorphism, Genetic * MeSH
- Fatty Acid-Binding Proteins genetics metabolism MeSH
- Cattle MeSH
- Muscles metabolism MeSH
- Fatty Acid Synthases genetics metabolism MeSH
- Transcription Factors genetics metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Diacylglycerol O-Acyltransferase MeSH
- Fatty Acids MeSH
- Fatty Acid-Binding Proteins MeSH
- Fatty Acid Synthases MeSH
- Transcription Factors MeSH
Allelic and genotypic distribution of polymorphisms in diacylglycerol acyltransferase 1 (DGAT1), fatty acid binding protein 4 (FABP4), fatty acid synthase (FASN), and peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) genes were assessed in 679 Fleckvieh bulls. Single-locus genotype effects and the combined effect of the two polymorphisms within the FASN gene were evaluated for association with the intramuscular fat content and fatty acid profile determined in muscle and subcutaneous fat. The FASN (g.16024G>A) and FASN (g.17924A>G) polymorphisms were significantly associated mainly with C14:0, C16:0, and C18:1 n-9 concentrations as well as with the atherogenic index. The proportion of explained phenotypic variation markedly increased when the effect of a combination of the two polymorphisms within the FASN gene was tested, with the highest values of 8.6% and 14.8%, respectively, observed for C14:0 in muscle and subcutaneous fat. With a focus on improving the fatty acid composition of beef, the results of this study provide valuable information about the markers applicable in marker-assisted selection.
References provided by Crossref.org
