Mitochondrial dysfunction in DDR-related cancer predisposition syndromes
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
26926806
DOI
10.1016/j.bbcan.2016.02.006
PII: S0304-419X(16)30022-1
Knihovny.cz E-zdroje
- Klíčová slova
- Autophagy, Cancer predisposition syndromes, DNA damage and repair, Mitochondrial dysfunction, Mitophagy, Oxidative stress, ROS,
- MeSH
- autofagie MeSH
- lidé MeSH
- mitochondrie fyziologie MeSH
- nádory etiologie MeSH
- poškození DNA * MeSH
- syndrom MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy.
Citace poskytuje Crossref.org
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