Mitochondrial dysfunction in DDR-related cancer predisposition syndromes
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
26926806
DOI
10.1016/j.bbcan.2016.02.006
PII: S0304-419X(16)30022-1
Knihovny.cz E-resources
- Keywords
- Autophagy, Cancer predisposition syndromes, DNA damage and repair, Mitochondrial dysfunction, Mitophagy, Oxidative stress, ROS,
- MeSH
- Autophagy MeSH
- Humans MeSH
- Mitochondria physiology MeSH
- Neoplasms etiology MeSH
- DNA Damage * MeSH
- Syndrome MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy.
References provided by Crossref.org
Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
