Dizocilpine (MK-801) impairs learning in the active place avoidance task but has no effect on the performance during task/context alternation
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
PubMed
26970577
DOI
10.1016/j.bbr.2016.03.020
PII: S0166-4328(16)30145-0
Knihovny.cz E-zdroje
- Klíčová slova
- Active place avoidance, Context alternation, Dizocilpine, Morris water maze, Schizophrenia, Task alternation,
- MeSH
- analýza rozptylu MeSH
- antagonisté excitačních aminokyselin toxicita MeSH
- bludiště - učení účinky léků MeSH
- dizocilpinmaleát toxicita MeSH
- krysa rodu Rattus MeSH
- lokomoce účinky léků MeSH
- modely nemocí na zvířatech MeSH
- poruchy učení chemicky indukované patofyziologie MeSH
- potkani Long-Evans MeSH
- reakční čas účinky léků MeSH
- učení vyhýbat se účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- antagonisté excitačních aminokyselin MeSH
- dizocilpinmaleát MeSH
The prevention of engram interference, pattern separation, flexibility, cognitive coordination and spatial navigation are usually studied separately at the behavioral level. Impairment in executive functions is often observed in patients suffering from schizophrenia. We have designed a protocol for assessing these functions all together as behavioral separation. This protocol is based on alternated or sequential training in two tasks testing different hippocampal functions (the Morris water maze and active place avoidance), and alternated or sequential training in two similar environments of the active place avoidance task. In Experiment 1, we tested, in adult rats, whether the performance in two different spatial tasks was affected by their order in sequential learning, or by their day-to-day alternation. In Experiment 2, rats learned to solve the active place avoidance task in two environments either alternately or sequentially. We found that rats are able to acquire both tasks and to discriminate both similar contexts without obvious problems regardless of the order or the alternation. We used two groups of rats, controls and a rat model of psychosis induced by a subchronic intraperitoneal application of 0.08mg/kg of dizocilpine (MK-801), a non-competitive antagonist of NMDA receptors. Dizocilpine had no selective effect on parallel/sequential learning of tasks/contexts. However, it caused hyperlocomotion and a significant deficit in learning in the active place avoidance task regardless of the task alternation. Cognitive coordination tested by this task is probably more sensitive to dizocilpine than spatial orientation because no hyperactivity or learning impairment was observed in the Morris water maze.
Institute of Physiology of the Czech Academy of Sciences Videnska 1083 14220 Prague 4 Czech Republic
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