Nanocarbon Allotropes-Graphene and Nanocrystalline Diamond-Promote Cell Proliferation
Language English Country Germany Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- carbon allotropes, cell adhesion, cell proliferation, graphene, nanocrystalline diamonds,
- MeSH
- Diamond pharmacology MeSH
- Photoelectron Spectroscopy MeSH
- Graphite pharmacology MeSH
- Stem Cells drug effects MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Microscopy, Atomic Force MeSH
- Microscopy, Electron, Scanning MeSH
- Nanoparticles * MeSH
- Cell Proliferation drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Diamond MeSH
- Graphite MeSH
Two profoundly different carbon allotropes - nanocrystalline diamond and graphene - are of considerable interest from the viewpoint of a wide range of biomedical applications including implant coating, drug and gene delivery, cancer therapy, and biosensing. Osteoblast adhesion and proliferation on nanocrystalline diamond and graphene are compared under various conditions such as differences in wettability, topography, and the presence or absence of protein interlayers between cells and the substrate. The materials are characterized in detail by means of scanning electron microscopy, atomic force microscopy, photoelectron spectroscopy, Raman spectroscopy, and contact angle measurements. In vitro experiments have revealed a significantly higher degree of cell proliferation on graphene than on nanocrystalline diamond and a tissue culture polystyrene control material. Proliferation is promoted, in particular, by hydrophobic graphene with a large number of nanoscale wrinkles independent of the presence of a protein interlayer, i.e., substrate fouling is not a problematic issue in this respect. Nanowrinkled hydrophobic graphene, thus, exhibits superior characteristics for those biomedical applications where high cell proliferation is required under differing conditions.
References provided by Crossref.org
Carbon Nanostructures, Nanolayers, and Their Composites
Inhibition of E. coli Growth by Nanodiamond and Graphene Oxide Enhanced by Luria-Bertani Medium
Initial cell adhesion of three cell types in the presence and absence of serum proteins
