Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe
Language English Country United States Media print-electronic
Document type Journal Article, Multicenter Study
PubMed
27012361
DOI
10.1111/epi.13347
Knihovny.cz E-resources
- Keywords
- Electromagnetic source imaging, Epilepsy surgery, Magnetic resonance imaging, Positron emission tomography, Single-photon emission computed tomography,
- MeSH
- Epilepsy diagnostic imaging physiopathology surgery MeSH
- Humans MeSH
- International Cooperation MeSH
- Neuroimaging * methods statistics & numerical data trends MeSH
- Image Processing, Computer-Assisted MeSH
- Surveys and Questionnaires MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Geographicals
- Europe epidemiology MeSH
OBJECTIVE: In 2014 the European Union-funded E-PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic source localization, and imaging postprocessing procedures in participating centers. METHODS: A survey on the clinical use of imaging, electromagnetic source localization, and postprocessing methods in epilepsy surgery candidates was distributed among the 25 centers of the consortium. A descriptive analysis was performed, and results were compared to existing guidelines and recommendations. RESULTS: Response rate was 96%. Standard epilepsy magnetic resonance imaging (MRI) protocols are acquired at 3 Tesla by 15 centers and at 1.5 Tesla by 9 centers. Three centers perform 3T MRI only if indicated. Twenty-six different MRI sequences were reported. Six centers follow all guideline-recommended MRI sequences with the proposed slice orientation and slice thickness or voxel size. Additional sequences are used by 22 centers. MRI postprocessing methods are used in 16 centers. Interictal positron emission tomography (PET) is available in 22 centers; all using 18F-fluorodeoxyglucose (FDG). Seventeen centers perform PET postprocessing. Single-photon emission computed tomography (SPECT) is used by 19 centers, of which 15 perform postprocessing. Four centers perform neither PET nor SPECT in children. Seven centers apply magnetoencephalography (MEG) source localization, and nine apply electroencephalography (EEG) source localization. Fourteen combinations of inverse methods and volume conduction models are used. SIGNIFICANCE: We report a large variation in the presurgical diagnostic workup among epilepsy surgery centers across Europe. This diversity underscores the need for high-quality systematic reviews, evidence-based recommendations, and harmonization of available diagnostic presurgical methods.
Center of Neurology Vilnius University Hospital Santariškių Klinikos Vilnius Lithuania
Claudio Munari Epilepsy Surgery Center Niguarda Hospital Milan Italy
Clinic of Neurology and Neurosurgery Faculty of Medicine Vilnius University Vilnius Lithuania
Department 6 Pediatric Neurology Clinic Carol Davila University of Medicine Bucharest Romania
Department of Clinical and Experimental Epilepsy University College London London United Kingdom
Department of Clinical Neurosciences Lausanne University Hospital Lausanne Switzerland
Department of Complex Epilepsy National Center for Epilepsy Oslo Norway
Department of Epileptology University Medical Center University of Bonn Bonn Germany
Department of Neurology Kuopio University Hospital Kuopio Finland
Department of Neurology Medical University of Innsbruck Innsbruck Austria
Department of Neurology Zagreb Epilepsy Center University Hospital Zagreb Croatia
Department of Neurosurgery Clinic of Surgery and Neuroscience Oslo University Hospital Oslo Norway
Department of Neurosurgery Epilepsy Surgery Center St Ivan Rilski University Hospital Sofia Bulgaria
Department of Psychology Uskudar University Uskudar Istanbul Turkey
Kork Epilepsy Center Kehl Kork Germany
Medical and Surgical Epilepsy Unit Hautepierre Hospital University of Strasbourg Strasbourg France
MR Research Center Semmelweis University Budapest Hungary
MRI Unit Epilepsy Society Chalfont St Peter United Kingdom
National Institute of Clinical Neurosciences Budapest Hungary
Pediatric Neurology Clinic Alexandru Obregia Clinical Psychiatric Hospital Bucharest Romania
School of Medicine University of Eastern Finland Kuopio Finland
Scientific Research Institute of Emergency Care named after N 5 Sklifosovsky Moscow Russia
Translational Imaging Group CMIC University College London London United Kingdom
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