HbA1c but not diabetes duration predicts increased arterial stiffness in adolescents with poorly controlled type 1 diabetes
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
27075550
DOI
10.1111/pedi.12385
Knihovny.cz E-zdroje
- Klíčová slova
- adolescents, arterial stiffness, blood pressure, pulse wave velocity, type 1 diabetes,
- MeSH
- analýza pulzové vlny MeSH
- biologické markery krev MeSH
- diabetes mellitus 1. typu krev komplikace patofyziologie terapie MeSH
- diabetická kardiomyopatie epidemiologie prevence a kontrola MeSH
- diabetické angiopatie epidemiologie prevence a kontrola MeSH
- glykovaný hemoglobin analýza MeSH
- hyperglykemie prevence a kontrola MeSH
- kardiovaskulární nemoci komplikace epidemiologie prevence a kontrola MeSH
- kohortové studie MeSH
- kombinovaná terapie MeSH
- konziliární vyšetření a konzultace MeSH
- lidé MeSH
- mladiství MeSH
- nemocnice univerzitní MeSH
- prevalence MeSH
- progrese nemoci MeSH
- průřezové studie MeSH
- rizikové faktory MeSH
- tuhost cévní stěny * MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- biologické markery MeSH
- glykovaný hemoglobin MeSH
- hemoglobin A1c protein, human MeSH Prohlížeč
BACKGROUND: The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have been performed in children with T1D. OBJECTIVE: To explore the risk factors associated with AS in adolescents with suboptimally controlled T1D. PATIENTS AND METHODS: Seventy-seven adolescents with T1D were included (39 girls, 38 boys) in this study. The adolescents had a median age of 16 yr (IQR 14-17), median duration of T1D was 9 yr (IQR 6-16), and HbA1c 71 mmol/mol (median, IQR 62-81). PWV was measured as the carotid-femoral pulse transmission time and converted into standard deviation scores (SDS) (adjusted for gender and age) using normative values for children. The risk factors assessed were HbA1c, T1D duration, treatment modality, serum lipids, and blood pressure (BP) measured via ambulatory blood pressure monitoring (ABPM). RESULTS: The PWV did not differ from the reference data (median PWV was 5.1 m/s, i.e., -0.01 SDS). A significant positive association was observed between PWV-SDS and HbA1c (p = 0.001), total cholesterol (p = 0.003), LDL-cholesterol (p = 0.003), but not T1D duration (p = 0.78) according to the univariate analyses. In the multivariate model, the only significant variable that remained positively associated with PWV-SDS was HbA1c (p = 0.03). CONCLUSIONS: Most adolescents with suboptimally controlled T1D have normal mean PWV compared to a healthy reference population. Chronic hyperglycemia, not T1D duration, is the main predictor of AS in adolescents.
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