Relapse in schizophrenia: Definitively not a bolt from the blue
Language English Country Ireland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
27109788
DOI
10.1016/j.neulet.2016.04.044
PII: S0304-3940(16)30265-8
Knihovny.cz E-resources
- Keywords
- Early warning signs, Information technology, Prevention, Relapse, Schizophrenia, Telemedicine,
- MeSH
- Chronic Disease MeSH
- Adult MeSH
- Humans MeSH
- Prodromal Symptoms MeSH
- Surveys and Questionnaires MeSH
- Recurrence MeSH
- Retrospective Studies MeSH
- Schizophrenic Psychology * MeSH
- Schizophrenia diagnosis prevention & control MeSH
- Secondary Prevention MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Detailed study of the period before schizophrenic relapse when early warning signs (EWS) are present is crucial to effective pre-emptive strategies. To investigate the temporal properties of EWS self-reported weekly via a telemedicine system. EWS history was obtained for 61 relapses resulting in hospitalization involving 51 patients with schizophrenia. Up to 20 weeks of EWS history per case were evaluated using a non-parametric bootstrap test and generalized mixed-effects model to test the significance and homogeneity of the findings. A statistically significant increase in EWS sum score was detectable 5 weeks before hospitalization. However, analysis of EWS dynamics revealed a gradual, monotonic increase in EWS score across during the 8 weeks before a relapse. The findings-in contrast to earlier studies-suggest that relapse is preceded by a lengthy period during which pathophysiological processes unfold; these changes are reflected in subjective EWS.
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