Can renal ultrasonography and DMSA scintigraphy be used for the prediction of irreversible histological lesions of the upper pole in duplex system with ureteroceles or ectopic ureters?
Language English Country Czech Republic Media print-electronic
Document type Comparative Study, Evaluation Study, Journal Article
PubMed
27174196
DOI
10.5507/bp.2016.028
Knihovny.cz E-resources
- Keywords
- duplex kidney, ectopic ureter, renal scintigraphy, ultrasonography, ureterocele,
- MeSH
- Child MeSH
- Infant MeSH
- Succimer MeSH
- Kidney abnormalities MeSH
- Humans MeSH
- Child, Preschool MeSH
- Prospective Studies MeSH
- Radionuclide Imaging MeSH
- ROC Curve MeSH
- Ultrasonography MeSH
- Ureter abnormalities MeSH
- Ureterocele diagnostic imaging MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Comparative Study MeSH
- Names of Substances
- Succimer MeSH
AIM: To assess of the role of renal ultrasonography (US) and DMSA renal scintigraphy in the prediction of irreversible histological lesions of the upper pole in duplex system. METHODS: A prospective cohort study based on data collected between 2005 and 2012 at our institution. The cohort consisted of 23 patients with ureteroceles and 28 patients with ectopic ureters who underwent upper pole nephrectomy. Preoperative recordings from ultrasound and nuclear renal scans were compared with the histological findings. Histological irreversible lesions were defined as the presence of dysplasia and/or severe chronic interstitial nephritis (CIN) in ≥ 90% of the specimen. ROC (Receiver Operating Characteristic) curves were used to investigate thresholds in order to identify irreversible lesions using various differential functions. The histology was correlated with the results of imaging. RESULTS: Pathological findings were found in all histological samples. Histological lesions were irreversible in 20/23 patients (87.0%) with ureteroceles and in 14/28 patients (50.0%) with ectopic ureters. The model is able to predict irreversible lesions if an upper pole differential function is ≤ 3% in patients with ureteroceles, and ≤ 2% in the presence of ectopic ureters. Weak association between parenchymal thinning on ultrasonography and irreversible lesions was found in patients with ectopic ureters. CONCLUSION: DMSA renal scintigraphy provides a useful tool for the prediction of irreversible lesions in the upper pole. Low differential function (≤ 3% and ≤ 2%, respectively) indicates irreversible lesions, favoring heminephrectomy. Higher differential function indicates greater remaining biological potential of the parenchyma, favoring reconstruction of the upper pole.
Department of Nuclear Medicine University Hospital Olomouc Czech Republic
Department of Paediatrics University Hospital Olomouc Czech Republic
Department of Urology University Hospital Olomouc Czech Republic
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