Francisella tularensis is the causative agent of the potentially lethal disease tularemia. Due to a low infectious dose and ease of airborne transmission, Francisella is classified as a category A biological agent. Despite the possible risk to public health, there is no safe and fully licensed vaccine. A potential vaccine candidate, an attenuated live vaccine strain, does not fulfil the criteria for general use. In this review, we will summarize existing and new candidates for live attenuated and subunit vaccines.

Department of Molecular Pathology and Biology Faculty of Military Health Sciences University of Defense Trebesska 1575 500 01 Hradec Kralove Czech Republic

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Innate Immune Recognition: Implications for the Interaction of Francisella tularensis with the Host Immune System