Differences between mesial and neocortical magnetic-resonance-imaging-negative temporal lobe epilepsy
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
27263079
DOI
10.1016/j.yebeh.2016.04.027
PII: S1525-5050(16)30041-5
Knihovny.cz E-resources
- Keywords
- Clinical semiology, Invasive EEG, MRI-negative temporal lobe epilepsy, Mesial MRI-negative TLE, Neocortical MRI-negative TLE, Positron emission tomography, Semiinvasive EEG,
- MeSH
- Child MeSH
- Adult MeSH
- Electroencephalography MeSH
- Epilepsy, Temporal Lobe diagnostic imaging surgery MeSH
- Fluorodeoxyglucose F18 MeSH
- Infant MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Adolescent MeSH
- Young Adult MeSH
- Brain diagnostic imaging MeSH
- Neocortex diagnostic imaging MeSH
- Neurosurgical Procedures MeSH
- Positron-Emission Tomography MeSH
- Child, Preschool MeSH
- Radiopharmaceuticals MeSH
- Retrospective Studies MeSH
- Temporal Lobe diagnostic imaging MeSH
- Age of Onset MeSH
- Treatment Outcome MeSH
- Seizures diagnostic imaging physiopathology MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Fluorodeoxyglucose F18 MeSH
- Radiopharmaceuticals MeSH
OBJECTIVE: The aim of this study was to assess clinical and electrophysiological differences within a group of patients with magnetic-resonance-imaging-negative temporal lobe epilepsy (MRI-negative TLE) according to seizure onset zone (SOZ) localization in invasive EEG (IEEG). METHODS: According to SOZ localization in IEEG, 20 patients with MRI-negative TLE were divided into either having mesial SOZ-mesial MRI-negative TLE or neocortical SOZ-neocortical MRI-negative TLE. We evaluated for differences between these groups in demographic data, localization of interictal epileptiform discharges (IEDs), and the ictal onset pattern in semiinvasive EEG and in ictal semiology. RESULTS: Thirteen of the 20 patients (65%) had mesial MRI-negative TLE and 7 of the 20 patients (35%) had neocortical MRI-negative TLE. The differences between mesial MRI-negative TLE and neocortical MRI-negative TLE were identified in the distribution of IEDs and in the ictal onset pattern in semiinvasive EEG. The patients with neocortical MRI-negative TLE tended to have more IEDs localized outside the anterotemporal region (p=0.031) and more seizures without clear lateralization of ictal activity (p=0.044). No other differences regarding demographic data, seizure semiology, surgical outcome, or histopathological findings were found. CONCLUSIONS: According to the localization of the SOZ, MRI-negative TLE had two subgroups: mesial MRI-negative TLE and neocortical MRI-negative TLE. The groups could be partially distinguished by an analysis of their noninvasive data (distribution of IEDs and lateralization of ictal activity). This differentiation might have an impact on the surgical approach.
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