Correlation between apoptosis distribution and BMP-2 and BMP-4 expression in vestigial tooth primordia in mice
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Apoptosis physiology MeSH
- Embryonic and Fetal Development MeSH
- Epithelium embryology metabolism MeSH
- Bone Morphogenetic Proteins biosynthesis genetics MeSH
- Bone Morphogenetic Protein 2 MeSH
- Bone Morphogenetic Protein 4 MeSH
- Mice MeSH
- Odontogenesis physiology MeSH
- Transforming Growth Factor beta * MeSH
- Gene Expression Regulation, Developmental MeSH
- Tooth Germ embryology metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bmp2 protein, mouse MeSH Browser
- Bmp4 protein, mouse MeSH Browser
- Bone Morphogenetic Proteins MeSH
- Bone Morphogenetic Protein 2 MeSH
- Bone Morphogenetic Protein 4 MeSH
- Transforming Growth Factor beta * MeSH
The eutherian dental formula consists of three incisors, one canine, four premolars and three molars in each dental quadrant. Muroid evolution led to a reduction in the number of teeth, with one incisor separated from three molars by a long diastema. However, seven vestigial tooth primordia (D1-5, R1-2) have been detected in the embryonic diastemal area of the mouse maxilla between embryonic days (ED) 12.5 and 13.5. Computer-aided 3D reconstructions were used to analyse the temporo-spatial pattern of apoptosis during regression in the two largest and most distal vestiges (R1, R2). These structures have been widely considered as the primordium of the first upper molar and, accordingly, related molecular data have been interpreted exclusively in terms of progressive molar development. The spatial distribution of epithelial apoptosis, which affected the R1 and R2 rudiments in two consecutive waves on ED 12.5 and 13.5, respectively, was compared with our earlier data on expression of genes encoding bone morphogenetic proteins (BMP-2 and BMP-4). Similar temporo-spatial patterns of apoptosis and expression of BMP, specifically confined to the epithelium of the rudimentary tooth primordia, strongly support involvement of BMPs in the regulation of epithelial apoptosis during odontogenesis.
References provided by Crossref.org
Role of Cell Death in Cellular Processes During Odontogenesis
Three-dimensional analysis of the early development of the dentition
Apoptotic signaling in mouse odontogenesis
Craniopharyngioma: a case report and comparative galectin histochemical analysis
