Non-anaplastic peripheral T cell lymphoma in children and adolescents-an international review of 143 cases
Language English Country Germany Media print-electronic
Document type Journal Article, Multicenter Study
PubMed
27270301
DOI
10.1007/s00277-016-2722-y
PII: 10.1007/s00277-016-2722-y
Knihovny.cz E-resources
- Keywords
- Non-Hodgkin’s lymphoma, Peripheral T cell lymphoma, Prognosis, Subtypes,
- MeSH
- Child MeSH
- Outcome Assessment, Health Care methods MeSH
- Remission Induction MeSH
- Infant MeSH
- Combined Modality Therapy MeSH
- Humans MeSH
- International Cooperation MeSH
- Adolescent MeSH
- Young Adult MeSH
- Lymphoma, T-Cell, Peripheral therapy MeSH
- Child, Preschool MeSH
- Disease-Free Survival MeSH
- Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
- Retrospective Studies MeSH
- Hematopoietic Stem Cell Transplantation methods statistics & numerical data MeSH
- Check Tag
- Child MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
Peripheral T cell lymphomas (PTCL) are rare in children and adolescents, and data about outcome and treatment results are scarce. The present study is a joint, international, retrospective analysis of 143 reported cases of non-anaplastic PTCL in patients <19 years of age, with a focus on treatment and outcome features. One hundred forty-three patients, between 0.3 and 18.7 years old, diagnosed between 2000 and 2015 were included in the study. PTCL not otherwise specified was the largest subgroup, followed by extranodal NK/T cell lymphoma, hepatosplenic T cell lymphoma (HS TCL), and subcutaneous panniculitis-like T cell lymphoma (SP TCL). Probability of overall survival (pOS) at 5 years for the whole group was 0.56 ± 0.05, and probability of event-free survival was (pEFS) 0.45 ± 0.05. Patients with SP TCL had a good outcome with 5-year pOS of 0.78 ± 0.1 while patients with HS TCL were reported with 5-year pOS of only 0.13 ± 0.12. Twenty-five percent of the patients were reported to have a pre-existing condition, and this group had a dismal outcome with 5-year pOS of 0.29 ± 0.09. The distribution of non-anaplastic PTCL subtypes in pediatric and adolescent patients differs from what is reported in adult patients. Overall outcome depends on the subtype with some doing better than others. Pre-existing conditions are frequent and associated with poor outcomes. There is a clear need for subtype-based treatment recommendations for children and adolescents with PTCL.
Belarusian Research Center for Pediatric Oncology Hematology and Immunology Minsk Belarus
Clinic of Paediatrics Haemathology and Oncology Medical University of Gdansk Gdansk Poland
Department of Pediatric Oncology Hôpital des Enfants Toulouse France
Department of Pediatrics Sapporo Hokuyu Hospital Sapporo Japan
Pediatric Hematology and Oncology Semmelweis University Budapest Hungary
Pediatric Hematology and Oncology University Hospitals Leuven Leuven Belgium
Pediatric Hematology and Oncology University of Padova Padova Italy
Pediatric Oncology and Hematology University Hospital Brno Czech Republic
Princess Maxima Center for Pediatric Oncology Utrecht The Netherlands
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