Systemic Inflammatory Response After Open, Laparoscopic and Robotic Surgery in Endometrial Cancer Patients
Jazyk angličtina Země Řecko Médium print
Typ dokumentu časopisecké články
PubMed
27272805
PII: 36/6/2909
Knihovny.cz E-zdroje
- Klíčová slova
- Endometrial cancer, inflammatory response, nutrition, robotic surgery, surgical trauma,
- MeSH
- biologické markery MeSH
- C-reaktivní protein analýza MeSH
- dospělí MeSH
- interleukin-6 krev MeSH
- laparoskopie metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory endometria metabolismus chirurgie MeSH
- neopterin moč MeSH
- prospektivní studie MeSH
- roboticky asistované výkony metody MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- zánět etiologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- C-reaktivní protein MeSH
- interleukin-6 MeSH
- neopterin MeSH
AIM: To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. MATERIALS AND METHODS: A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively. RESULTS: The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups. CONCLUSION: The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma.
Neopterin as a biomarker of immune response in cancer patients
