Systemic Inflammatory Response After Open, Laparoscopic and Robotic Surgery in Endometrial Cancer Patients
Language English Country Greece Media print
Document type Journal Article
PubMed
27272805
PII: 36/6/2909
Knihovny.cz E-resources
- Keywords
- Endometrial cancer, inflammatory response, nutrition, robotic surgery, surgical trauma,
- MeSH
- Biomarkers MeSH
- C-Reactive Protein analysis MeSH
- Adult MeSH
- Interleukin-6 blood MeSH
- Laparoscopy methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Endometrial Neoplasms metabolism surgery MeSH
- Neopterin urine MeSH
- Prospective Studies MeSH
- Robotic Surgical Procedures methods MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Inflammation etiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- C-Reactive Protein MeSH
- Interleukin-6 MeSH
- Neopterin MeSH
AIM: To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. MATERIALS AND METHODS: A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively. RESULTS: The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups. CONCLUSION: The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma.
Neopterin as a biomarker of immune response in cancer patients
